Ventilation during CPR and outcomes in out-of-hospital cardiac arrest
Official title: Multi-center observational study of the association between ventilation and cardiac arrest outcome
Funded at Ut Southwestern Medical Center · NIH-11417180 · Data updated 2026-11-12
This project will look at how ventilation during CPR relates to survival in adults who have a cardiac arrest outside the hospital.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 16, 2025 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $413,540 |
| NIH project number | 5R01HL173101-02 |
| Project ID | NIH-11417180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older who experience out-of-hospital cardiac arrest and receive CPR, with data collected during standard resuscitation.
✕Less likely to help
Patients who do not experience OHCA or whose data are not part of the monitored CPR events may not benefit from study findings.
What this research studies
This study uses real-world data from multiple centers to measure how well ventilation happens during CPR in adults with out-of-hospital cardiac arrest. Researchers have developed a machine-learning tool to automatically detect ventilation during continuous chest compressions, allowing detailed analysis of ventilation patterns. The goal is to understand how ventilation timing and quality impact survival and neurological outcomes, informing future CPR guidelines and trial designs.
Why it matters
Potential benefit: If successful, the findings could help clinicians improve CPR methods and potentially increase survival rates after OHCA.
How similar studies have gone: Previous work showed that better measurement of ventilation during CPR is feasible and can reveal gaps in current practices; this study extends those findings to a larger, multi-center dataset.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Idris, Ahamed H — Ut Southwestern Medical Center
- Study coordinator: Idris, Ahamed H
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
-
Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
-
Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
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Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.