Condition

Acute Respiratory Failure clinical trials and research

• 27Clinical trials
• 38NIH research projects
• 13Countries

Newest Acute Respiratory Failure clinical trials

All recruiting trials (27)

• Sodium bicarbonate with bedside electrical impedance tomography to map lung blood flow in ventilated adults

  This project will try whether a small sodium bicarbonate injection combined with bedside electrical impedance tomography can map lung blood flow in adults on mechanical ventilation, compared with hypertonic saline.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07542366

• Feasibility of using a weight-adjusted saline bolus with electrical impedance tomography to map lung perfusion in children

  This pediatric pilot tests whether a carefully dosed saline bolus with electrical impedance tomography can map lung perfusion and ventilation distribution in kids with acute respiratory failure.

  Recruiting Hospices Civils de Lyon · Bron, France · NCT07532811

• Predicting HFNO failure within 72 hours using a physiology-informed model at 30 minutes

  This study tests a model that uses Heart–lung physiology and 30-minute data to see if high-flow nasal oxygen will fail in adults with acute hypoxemic respiratory failure.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT07366541

• Bedside ultrasound of the IVC to find pulmonary edema in adults with sudden severe breathlessness

  This project will test whether bedside ultrasound measurements of how the inferior vena cava changes with breathing can help identify pulmonary edema in adults who come to the emergency department with sudden breathing failure.

  Recruiting Università degli Studi del Piemonte Orientale Amedeo Avogadro · Novara · NCT07324980

• Brain–lung interaction during sudden severe low-oxygen respiratory failure

  We will try EEG, NIRS, and neck muscle recordings before and one hour after starting high-flow nasal oxygen in adults with sudden low-oxygen respiratory failure to see how the brain and lungs interact.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT07279831

• Comparing SpO2 targets and oximeters during high-flow nasal oxygen

  This study tests whether two different pulse oximeters (Nonin and Philips) and two SpO2 targets (90% vs 94%) change the amount of oxygen (FiO2) set for adults in the ICU receiving high-flow nasal oxygen.

  Recruiting Laval University · Québec, Quebec · NCT07168213

• Correlation of clinical and breathing measures with failure of non-invasive respiratory support in acute respiratory failure

  This project will try to see if routine clinical signs and breathing measurements can predict when high-flow oxygen or non-invasive ventilation won't prevent the need for a breathing tube in adults with acute respiratory failure.

  Recruiting University of Modena and Reggio Emilia · Modena · NCT06989385

• Comparing waveform capnography and color-change CO2 detectors to confirm tube placement during intubation

  This study will test whether waveform capnography or color-change CO2 detectors better confirm endotracheal tube placement in critically ill adults during intubation.

  Recruiting at 7 sites Hennepin Healthcare Research Institute · Chicago, Illinois and 8 other locations · NCT06934876

• CPAP support for acute low-oxygen respiratory failure in Burkina Faso

  This program will try CPAP (a simple non‑electric breathing support) to see if it reduces the need for intubation in adults with acute low‑oxygen respiratory failure in Burkina Faso.

  Recruiting Université NAZI BONI · Bobo-Dioulasso, Houet and 3 other locations · NCT06912360

• Education on Immunosuppressive Therapy Reduction in Kidney Transplant Recipients in ICU with Sepsis or Respiratory Failure

  In kidney transplant patients who are in the ICU for septic shock or severe respiratory failure, the study will test a targeted approach to adjust immunosuppressive therapy and provide education to support safer care.

  Recruiting Phase 4 University Hospital, Strasbourg, France · Strasbourg · NCT06881927

• MiniLung petite kit for neonates and infants with severe respiratory or cardiac failure

  We will test whether the MiniLung petite kit with the Xenios console safely improves oxygenation, removes CO2, and stabilizes circulation in newborns and young infants (2–8 kg) with severe respiratory or cardiopulmonary failure.

  Recruiting at 2 sites Fresenius Medical Care Deutschland GmbH · Bonn, North Rhine-Westphalia and 1 other locations · NCT06750536

• Validating the BREF models for estimating breathing effort in ICU patients on high-flow nasal oxygen.

  This project tests whether BREF models can accurately estimate breathing effort from esophageal pressure recordings in adults in the ICU receiving high-flow nasal oxygen.

  Recruiting Istituto Clinico Humanitas · Rozzano, Milan · NCT06669312

• Developing an AI model for personalized medicine in acute respiratory failure

  This study is trying to create a new AI tool that helps doctors understand different types of patients with acute respiratory failure in the ICU and how they might respond to treatment.

  Recruiting Samsung Medical Center · Seoul, Gangnam · NCT06479421

• Two-way video support for paramedics caring for infants with life-threatening breathing problems.

  This project will test whether a two-way video link with pediatric emergency doctors helps paramedics give better care to infants with life-threatening breathing problems during transport.

  Recruiting at 4 sites Boston Medical Center · Los Angeles, California and 8 other locations · NCT06441760

• Understanding recovery expectations in acute respiratory failure survivors and their caregivers

  This study looks at how adults who survive acute respiratory failure and their caregivers feel about recovery in the first six months after leaving the hospital to see if shared expectations can help improve their mental health.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06401239

• Comparing closed-loop synchronization to conventional synchronization in noninvasive ventilation for breathing patients

  This study is testing if a new automatic breathing device helps adults using noninvasive ventilation breathe better compared to standard methods.

  Recruiting Başakşehir Çam & Sakura City Hospital · Izmir · NCT06357780

• Infusion of iloprost for 72 hours in patients on mechanical ventilation with acute respiratory failure

  This study is testing if giving a medication called iloprost for 72 hours can help patients on mechanical ventilation with severe breathing problems caused by infections feel better and live longer.

  Recruiting at 5 sites Phase 2 Copenhagen University Hospital, Rigshospitalet · Copenhagen and 4 other locations · NCT06319274

• Exhaled breath condensate analysis in mechanically ventilated ICU patients

  This project will collect small samples of exhaled breath condensate and blood from mechanically ventilated ICU patients to see if protein and molecular patterns can signal early lung or other organ problems.

  Recruiting at 2 sites The Institute of Molecular and Translational Medicine, Czech Republic · Olomouc and 1 other locations · NCT06189924

• Comparing closed-loop and conventional methods for ventilator synchronization in children

  This study is testing a new way to help ventilators work better with children who need breathing support in the hospital to see if it helps them breathe more comfortably.

  Recruiting at 5 sites Dr. Behcet Uz Children's Hospital · Aydin and 4 other locations · NCT05731024

• Observing oxygenation practices during fiberoptic bronchoscopy

  This study looks at how doctors provide oxygen and breathing support to adults during fiberoptic bronchoscopy to better understand current practices.

  Recruiting University Magna Graecia · Catanzaro · NCT05681962

• Using viscoelastic testing to guide tPA treatment for acute respiratory failure

  This study is testing if using a special blood test can help doctors decide when to give a treatment for blood clots to patients with acute respiratory failure, including those with COVID-19.

  Recruiting Phase 2 South West Sydney Local Health District · Liverpool, New South Wales · NCT05540834

• Monitoring ventilation distribution in children with respiratory failure using electrical impedance tomography

  This study is testing a new way to monitor how well children with breathing problems are getting air in their lungs to see how different treatments can help them breathe better.

  Recruiting at 4 sites Hospices Civils de Lyon · Bron, Rhone and 3 other locations · NCT05347563

• Assessing breathing effort in COVID-19 patients with respiratory failure

  This study is testing how breathing effort in COVID-19 patients with severe respiratory failure changes when they receive non-invasive support to help improve their care.

  Recruiting University of Modena and Reggio Emilia · Modena · NCT04666246

• Registry of extracorporeal life support cases in China

  This study collects information on patients using extracorporeal life support (ECLS) in China to see how well it helps with heart and lung problems over time.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT04158479

• Examining the link between esophageal pressure and respiratory support failure in patients with acute respiratory failure

  This study looks at how pressure in the esophagus relates to breathing support problems in patients with severe breathing issues, including those with COVID-19, to find better ways to help them.

  Recruiting University of Modena and Reggio Emilia · Modena · NCT03826797

• Registry of patients needing ECMO in Australia and New Zealand

  This study is creating a detailed database of patients in Australia and New Zealand who need ECMO for serious heart or lung problems to help improve treatment and outcomes for critically ill patients.

  Recruiting at 28 sites Australian and New Zealand Intensive Care Research Centre · Canberra, Australian Capital Territory and 28 other locations · NCT03793257

• Improving non-invasive ventilation for patients with acute respiratory failure

  This study looks at how well non-invasive ventilation works for people with acute respiratory failure to help improve their treatment.

  Recruiting Università Vita-Salute San Raffaele · Milan · NCT01571986

NIH-funded research (38)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using a simple breathing test to check lung function after kids’ acute respiratory failure

  A study will test a child-friendly breathing method (oscillometry) to check how well lungs work after severe respiratory illness in kids.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11530755

• Financial hardship in acute respiratory failure patients and their family caregivers

  This grant studies how money worries affect patients with acute respiratory failure and their family caregivers, aiming to improve outcomes for both sides.

  NIH research University of Washington · Seattle, United States · NIH-11411238

• Understanding which patients and hospital care pathways affect outcomes after ICU vs ward care for ARF and sepsis

  A big study using hospital records to figure out which patients with acute respiratory failure and sepsis do best when admitted to ICUs versus general wards.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11372276

• Optimizing Time-Limited Trials of Ventilation in Acute Respiration Failure

  Aimed at patients with acute respiratory failure, this project looks at how short-term trials of life-support in the ICU can be better planned and communicated.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11348199

• Using a simple breathing test to check how kids recover lung function after severe lung illness

  A study will test a quick, noninvasive breathing test called oscillometry to see how well children who survived dangerous lung problems recover over time.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11324603

• Breathing effort and ventilator safety in severe respiratory failure

  This research looks at how a person's own breathing effort affects lung and diaphragm injury for adults on ventilators for acute respiratory failure.

  NIH research New York University School of Medicine · New York, United States · NIH-11258593

• Helping survivors of acute respiratory failure manage anxiety

  This study is looking to help adults who have recovered from serious breathing problems feel less anxious by trying out a new self-help program, and it will start by talking to patients in the hospital to make sure the program meets their needs before testing it against regular care.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11201357

• Financial strain for adults with acute respiratory failure and their family caregivers

  This project looks at how medical bills, lost income, and money worries affect adults with acute respiratory failure and the family members who care for them.

  NIH research University of Washington · Seattle, United States · NIH-11171365

• Recovery expectations after acute breathing failure for survivors and their caregivers

  This project looks at how adults who survive sudden respiratory failure and their family or unpaid caregivers think about recovery and how those expectations affect coping and mental health.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11167560

• Why low-oxygen episodes in very premature babies can cause memory problems

  This work explores whether a brief low-oxygen event around birth changes how hippocampus cells mature and leads to lasting learning and memory problems in babies born very early.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11166447

• Understanding how care decisions affect outcomes for patients with breathing problems and sepsis

  This project looks at hospital records to understand how decisions about where patients with severe breathing issues and sepsis receive care affect their recovery.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11160556

• Understanding Fragmented Care for Acute Respiratory Failure

  This project looks at how different doctors caring for patients with acute respiratory failure might affect their recovery and what hospitals can do to help.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11136885

• Evaluating lung function in children after severe respiratory illness

  This study is looking at how to check lung health in young kids under 6 who have recovered from serious breathing problems, like those caused by pneumonia or asthma, using a gentle method that doesn't require them to do any tricky breathing exercises, so we can better understand how these issues affect their lungs in t

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11117616

• Understanding the risks of acute respiratory failure in patients with hospital-onset sepsis

  This study looks at how patients with hospital-onset sepsis might face different chances of developing breathing problems, and it aims to find better ways to treat those at higher risk so they can get the care they need to feel better.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11082526

• Respiratory drive and ventilator care in acute respiratory failure

  A study at NYU School of Medicine will explore how a patient’s own breathing effort affects lung injury during invasive ventilation in adults with acute respiratory failure.

  NIH research New York University School of Medicine · New York, United States · NIH-11082204

• Understanding aspiration risks in survivors of acute respiratory failure

  This study is looking at how to spot patients who might have trouble swallowing safely after they’ve been on a breathing machine, so we can help prevent serious problems like pneumonia and make their recovery easier.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11080989

• Improving care for patients with acute respiratory failure at the end of life

  This study is looking at ways to improve care for patients with severe breathing problems, especially those who are close to the end of their lives, by trying out short-term treatment plans that help everyone involved—patients, families, and doctors—make better decisions together about what care is best for them.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11077805

• Examining opioid use in patients with acute respiratory failure on ventilators

  This study looks at how doctors prescribe pain medications called opioids to patients who are on breathing machines due to serious lung problems, and it aims to understand how these medications affect their recovery and overall health in the long run, so we can improve pain management for people in critical care.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11027460

• Understanding why critically ill patients with respiratory failure and sepsis face health disparities.

  This study is looking into why critically ill patients with breathing problems and infections, especially those from minority backgrounds, often have worse health outcomes, and it aims to find ways to improve their care based on their unique challenges.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11018640

• Helping survivors of acute respiratory failure manage anxiety

  This study is looking to help adults who have recovered from serious breathing problems and are dealing with anxiety by testing a new program that teaches them how to manage their feelings better, so they can feel less anxious and improve their overall well-being.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11012252

• Understanding uncertainty and expectations in survivors of acute respiratory failure

  This study is looking at how people who have survived serious breathing problems feel about their health and recovery, and how this uncertainty affects their daily lives, so we can find better ways to support them after their hospital stay.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10998341

• Improving outcomes for survivors of acute respiratory failure through family-centered care

  This study is looking at a new way to help people recover better after they’ve had serious breathing problems by involving their families in the care process, and it’s designed for patients and their loved ones to work together for better health outcomes.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10984281

• Understanding how low oxygen affects memory in preterm infants

  This study looks at how low oxygen levels can affect memory and brain development in preterm babies who have had serious breathing problems, using a mouse model to help understand the long-term impacts on learning and memory.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10939062

• Understanding how ICU and ward care affects patients with severe respiratory issues and sepsis

  This study looks at how choosing to treat patients with serious breathing problems and infections in either intensive care units or regular hospital rooms affects their recovery, with the aim of finding ways to improve care for these patients.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10918227

• Using Ganciclovir to Prevent Cytomegalovirus Reactivation in Patients with Severe Respiratory Issues

  This study is looking at whether the antiviral medication ganciclovir can help prevent the reactivation of cytomegalovirus (CMV) in adults with severe respiratory failure caused by sepsis, to see if it can improve their recovery and reduce the time they spend on a ventilator and in the ICU.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10916408

• Using ganciclovir to stop cytomegalovirus from reactivating in patients with severe respiratory failure and sepsis

  This study is looking at whether the antiviral drug ganciclovir can help prevent a virus called cytomegalovirus (CMV) from coming back in adults who are seriously ill with respiratory failure from sepsis, and it’s for people who want to help improve treatment options for patients in critical condition.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10914214

• Understanding health expectations after surviving acute respiratory failure

  This study is looking at how patients who have recovered from serious breathing problems and their caregivers think about recovery, and it aims to understand the challenges they face together so that better support can be created for both groups.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10912017

• Examining racial differences in decision making for patients with severe breathing issues

  This study looks at how doctors and nurses in the ICU work with patients and their families, especially focusing on how Black and White families are involved in making tough decisions about breathing problems, with the goal of finding ways to make sure everyone gets the same level of care and support during these stres

  NIH research Duke University · Durham, United States · NIH-10910048

• Improving discussions about care goals for patients with serious illnesses and breathing problems

  This study is all about helping doctors and nurses talk better with patients who have long-term health issues and sudden breathing problems, so they can understand what matters most to you and make sure your care matches your wishes.

  NIH research University of Washington · Seattle, United States · NIH-10909005

• Understanding financial challenges faced by patients with acute respiratory failure and their caregivers

  This study is looking at how the financial struggles faced by patients with acute respiratory failure and their caregivers affect their mental health and quality of life, with the goal of finding better ways to support them.

  NIH research University of Washington · Seattle, United States · NIH-10908556

• Creating a new way to measure recovery for patients with acute respiratory failure

  This study is looking to create a better way to understand how well people recover after experiencing serious breathing problems, by focusing not just on how many days they spend out of the hospital, but also on how they feel and function in their daily lives.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10907774

• Examining the quality of palliative care for patients with chronic illness and respiratory failure

  This study looks at how well patients with long-term illnesses and breathing problems are cared for in hospitals, especially since the COVID-19 pandemic, to find ways to make their experience better and improve their quality of life.

  NIH research University of Washington · Seattle, United States · NIH-10898552

• Improving the use of effective treatments for acute respiratory failure

  This study is looking at ways to help doctors use the best treatments for patients with acute respiratory failure, a serious condition that many people face, so that more patients can get the care they need to recover in the hospital.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10888386

• Understanding how fragmented care affects patients with acute respiratory failure

  This study looks at how getting care from different doctors can affect patients with acute respiratory failure, aiming to find ways to improve their treatment and help them recover better after hospital stays.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10881744

• Examining how critically ill patients are transferred between hospitals for better care.

  This study, led by Dr. Christopher Worsham, is looking at how well hospitals transfer critically ill patients with breathing problems and aims to find ways to make these transfers safer and more effective for better patient care and lower costs.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10876987

• Using digital tools to assess recovery in children after severe respiratory failure

  This study is looking at how kids who had serious breathing problems and needed help with breathing can recover better, using cool gadgets to track their activity and lung health, so we can find ways to help them enjoy life and play like they used to after leaving the hospital.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10724042

• How alcohol misuse affects cognitive and respiratory health in COVID-19 patients

  This study is looking at how drinking too much alcohol might affect people with severe COVID-19 breathing problems, especially those on breathing machines, to see if it makes their thinking and breathing worse, and to find ways to help them recover better.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10671588

• Portable lung CT scans for patients with severe breathing problems

  This study is working on a small, portable CT scanner that can be used right in the ICU to help doctors quickly and accurately diagnose patients with serious breathing problems, making it safer and easier for them to get the care they need.

  NIH research Xoran Technologies, LLC · Ann Arbor, United States · NIH-10632085

Related topics

Quick answers

How many Acute Respiratory Failure clinical trials are recruiting right now?

27, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in Italy (7 trials), France (4 trials), United States (3 trials), China (3 trials), Australia (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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