Using magnesium to protect the brain after cardiac arrest
Neuroprotection Following Cardiac Arrest: A Randomized Control Trial of Magnesium
PHASE1 · NYU Langone Health · NCT06455514
This study is testing if giving magnesium to people who have survived a cardiac arrest can help protect their brain and reduce injury.
Quick facts
| Phase | PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 178 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | NYU Langone Health (other) |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT06455514 on ClinicalTrials.gov |
What this trial studies
This pilot interventional study aims to evaluate the safety and feasibility of administering magnesium sulfate as a neuroprotective treatment in patients who have achieved Return of Spontaneous Circulation (ROSC) following cardiac arrest. The study will measure serum markers of neuronal injury at specific time points after ROSC to gather preliminary data. With a limited sample size, the primary goal is to assess the precision and stability of these measures to inform future larger trials.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 85 who have achieved ROSC within 2 hours of cardiac arrest.
Not a fit: Patients with traumatic cardiac arrests or those who are expected to have life support withdrawn within 72 hours may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve neurological outcomes for patients who survive cardiac arrest.
How similar studies have performed: While this approach is novel, similar studies exploring neuroprotection after cardiac arrest have shown promise, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Documented post-cardiac arrest patient with Return of Spontaneous Circulation (ROSC) achieved \<2 hours prior to recruitment Exclusion Criteria: * Age \< 18 years or \> 85 years * Traumatic cardiac arrests * Unsustained ROSC (\<20 minutes) * Patient who is responsive/able to follow motor commands within 1 hour of achieving ROSC * Plan for withdrawal of life support within 72 hours of ROSC * Known pregnant women at the time of the cardiac arrest * Known prisoners at the time of the cardiac arrest * Subjects who have a medical o social condition that would make them inappropriate for the study based on the PI's or clinical team judgement.
Where this trial is running
New York, New York
- NYU Langone Health — New York, New York, United States (RECRUITING)
Study contacts
- Principal investigator: Sam Parnia — NYU Langone Health
- Study coordinator: Anelly Gonzales
- Email: resuscitationlab@nyulangone.org
- Phone: 646-501-6923
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiac Arrest, Return of Spontaneous Circulation