Using magnesium to protect the brain after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot interventional study aims to evaluate the safety and feasibility of administering magnesium sulfate as a neuroprotective treatment in patients who have achieved Return of Spontaneous Circulation (ROSC) following cardiac arrest. The study will measure serum markers of neuronal injury at specific time points after ROSC to gather preliminary data. With a limited sample size, the primary goal is to assess the precision and stability of these measures to inform future larger trials.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Documented post-cardiac arrest patient with Return of Spontaneous Circulation (ROSC) achieved \<2 hours prior to recruitment

Exclusion Criteria:

* Age \< 18 years or \> 85 years
* Traumatic cardiac arrests
* Unsustained ROSC (\<20 minutes)
* Patient who is responsive/able to follow motor commands within 1 hour of achieving ROSC
* Plan for withdrawal of life support within 72 hours of ROSC
* Known pregnant women at the time of the cardiac arrest
* Known prisoners at the time of the cardiac arrest
* Subjects who have a medical o social condition that would make them inappropriate for the study based on the PI's or clinical team judgement.

Where it's running

• NYU Langone Health
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Sam Parnia — NYU Langone Health
• Study coordinator: Anelly Gonzales
• Email: resuscitationlab@nyulangone.org
• Phone: 646-501-6923

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Heartsight helps caregivers of kids after cardiac arrest manage uncertainty and fear

  This pilot trial tests if the Heartsight information program is acceptable and helpful for caregivers of children who recently had a cardiac arrest.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT07707037

• Brain blood flow and brain regulation in critically ill kids

  This study tests how blood flow in the brain behaves in critically ill children using a noninvasive ultrasound (TCD) to see if brain autoregulation patterns relate to outcomes.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07613918

• Cardiopulmonary resuscitation with balloon occlusion of the descending aorta for hospitalized patients

  This trial will test whether adding a balloon occlusion of the descending aorta (REBOA) to standard ACLS helps people having an in-hospital cardiac arrest regain and keep a pulse.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT07434726

• Digital serious game to improve critical care nurses' targeted temperature management skills and situational awareness.

  We will test whether adding a digital serious game to regular lectures helps adult ICU nurses learn targeted temperature management and improve situational awareness.

  Recruiting National Taiwan University Hospital · Taipei, Taipei · NCT07239206

• Plasma proteins, metabolites, and platelet changes in extracorporeal CPR for cardiac arrest patients

  This project will test whether patterns in blood proteins, small molecules, and platelet shape changes can help identify which adults with cardiac arrest might benefit from extracorporeal CPR.

  Recruiting Central China Fuwai Hospital of Zhengzhou University · Zhengzhou, Henan · NCT07113769

• Targeted Temperature Management at 33°C for in-hospital cardiac arrest

  This trial tests whether cooling patients who remain unconscious after a resuscitated in-hospital cardiac arrest to 33°C improves survival with good brain function compared to keeping a normal, controlled temperature.

  Recruiting at 31 sites Nantes University Hospital · Ghent, Belgium and 30 other locations · NCT07086703

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.