Registry and tissue repository for comatose cardiac arrest patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop a reliable assessment algorithm for predicting neurological outcomes in comatose patients following cardiac arrest. It will collect extensive data on demographics, cardiac arrest details, post-resuscitation care, and various prognostic assessments at standardized time points. The study will involve an international cohort, with a derivation subset for creating a prediction model and a validation subset to confirm its accuracy. Additionally, it will explore the impact of life-sustaining therapy withdrawal practices on outcome predictions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Initially unconscious following cardiac arrest from any non-perfusing rhythm (i.e., ventricular tachycardia, ventricular fibrillation, pulseless electrical activity, asystole)
* Sustained return of spontaneous circulation (ROSC) as defined by maintained spontaneous circulation for at least 20 minutes after cardiopulmonary resuscitation.

Exclusion Criteria:

\- Isolated respiratory arrest without concomitant or ensuing cardiac arrest

Where it's running

• University of California, San Francisco
  San Francisco, California, United States Recruiting
• Yale University
  New Haven, Connecticut, United States Recruiting
• University of Florida
  Gainesville, Florida, United States Recruiting
• Boston Medical Center
  Boston, Massachusetts, United States Recruiting
• University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting
• Instituto D'Or de Pesquisa e Ensino
  Rio de Janeiro, Brazil Recruiting

Study contacts

• Principal investigator: David M Greer, MD MA — Boston Medical Center, Neurology
• Study coordinator: David M Greer, MD MA
• Email: dgreer@bu.edu
• Phone: (617) 638-5102

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Cardiopulmonary resuscitation with balloon occlusion of the descending aorta for hospitalized patients

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• Plasma proteins, metabolites, and platelet changes in extracorporeal CPR for cardiac arrest patients

  This project will test whether patterns in blood proteins, small molecules, and platelet shape changes can help identify which adults with cardiac arrest might benefit from extracorporeal CPR.

  Recruiting Central China Fuwai Hospital of Zhengzhou University · Zhengzhou, Henan · NCT07113769

• Targeted Temperature Management at 33°C for in-hospital cardiac arrest

  This trial tests whether cooling patients who remain unconscious after a resuscitated in-hospital cardiac arrest to 33°C improves survival with good brain function compared to keeping a normal, controlled temperature.

  Recruiting at 31 sites Nantes University Hospital · Ghent, Belgium and 30 other locations · NCT07086703

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.