Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Monitoring and optimizing brain blood flow in patients after cardiac arrest

Official title: Monitoring and Optimization of Cerebral Perfusion Pressure in Post-cardiac Arrest Patients: a Pilot Study

Run by National Taiwan University Hospital · NCT06601842 · Data updated 2026-11-12

This study is testing a way to monitor and improve blood flow in the brain for patients who have survived cardiac arrest to see if it helps their recovery.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment50 (estimated)
SponsorNational Taiwan University Hospital
Academic / other
Locations1 site (Taipei)
StatusRecruiting
StartedDecember 10, 2024
Main results expectedAugust 2028
Study endsDecember 2028
Registry record updatedSeptember 18, 2026
Trial IDNCT06601842 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include non-traumatic cardiac arrest patients admitted to the ICU with a Glasgow Coma Scale (GCS) motor score of 5 or less.

Probably not a fit

Patients with traumatic cardiac arrest, pregnancy, or severe pre-existing conditions such as intracranial hemorrhage or coagulopathy may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to establish a process for monitoring intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in patients who have experienced cardiac arrest. It will analyze the correlation between direct and non-invasive ICP monitoring indicators and develop protocols for managing elevated ICP and insufficient CPP. The study will also focus on personalizing CPP and mean arterial pressure (MAP) optimization to improve neuroprognosis in these patients. Participants will receive ICP monitoring within 12 hours after regaining spontaneous circulation if they meet the inclusion criteria.

Why it matters

Potential benefit: If successful, this study could lead to improved outcomes and neuroprotection for patients recovering from cardiac arrest.

How similar studies have gone: While direct ICP monitoring in cardiac arrest patients is not routinely practiced, the study's approach is innovative and may provide new insights into post-arrest care.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* non-traumatic cardiac arrest
* admitted to ICU
* GCS: motor \<=5
* severity: TIMECARD score medium-risk group

Exclusion Criteria:

* traumatic cardiac arrest
* pregnancy
* intracranial hemorrhage
* coagulopathy
* anti-platelet or anti-coagulation use
* terminal illness
* pre-arrest CPC score \>=3
* GWR \< 1.2 on CT or severe hypoxic ischemic encephalopathy
* CNS infection

Where it's running

  • National Taiwan University Hospital
    Taipei, Taiwan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.