Monitoring and optimizing brain blood flow in patients after cardiac arrest
Official title: Monitoring and Optimization of Cerebral Perfusion Pressure in Post-cardiac Arrest Patients: a Pilot Study
Run by National Taiwan University Hospital · NCT06601842 · Data updated 2026-11-12
This study is testing a way to monitor and improve blood flow in the brain for patients who have survived cardiac arrest to see if it helps their recovery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | December 10, 2024 |
| Main results expected | August 2028 |
| Study ends | December 2028 |
| Registry record updated | September 18, 2026 |
| Trial ID | NCT06601842 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include non-traumatic cardiac arrest patients admitted to the ICU with a Glasgow Coma Scale (GCS) motor score of 5 or less.
✕Probably not a fit
Patients with traumatic cardiac arrest, pregnancy, or severe pre-existing conditions such as intracranial hemorrhage or coagulopathy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot study aims to establish a process for monitoring intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in patients who have experienced cardiac arrest. It will analyze the correlation between direct and non-invasive ICP monitoring indicators and develop protocols for managing elevated ICP and insufficient CPP. The study will also focus on personalizing CPP and mean arterial pressure (MAP) optimization to improve neuroprognosis in these patients. Participants will receive ICP monitoring within 12 hours after regaining spontaneous circulation if they meet the inclusion criteria.
Why it matters
Potential benefit: If successful, this study could lead to improved outcomes and neuroprotection for patients recovering from cardiac arrest.
How similar studies have gone: While direct ICP monitoring in cardiac arrest patients is not routinely practiced, the study's approach is innovative and may provide new insights into post-arrest care.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * non-traumatic cardiac arrest * admitted to ICU * GCS: motor \<=5 * severity: TIMECARD score medium-risk group Exclusion Criteria: * traumatic cardiac arrest * pregnancy * intracranial hemorrhage * coagulopathy * anti-platelet or anti-coagulation use * terminal illness * pre-arrest CPC score \>=3 * GWR \< 1.2 on CT or severe hypoxic ischemic encephalopathy * CNS infection
Where it's running
-
National Taiwan University Hospital
Taipei, Taiwan Recruiting
Study contacts
- Study coordinator: Dean-An Ling, MD
- Email: speckle0714@gmail.com
- Phone: +886-02-23123456
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.