Monitoring and optimizing brain blood flow in patients after cardiac arrest
Monitoring and Optimization of Cerebral Perfusion Pressure in Post-cardiac Arrest Patients: a Pilot Study
NA · National Taiwan University Hospital · NCT06601842
This study is testing a way to monitor and improve blood flow in the brain for patients who have survived cardiac arrest to see if it helps their recovery.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | National Taiwan University Hospital (other) |
| Locations | 1 site (Taipei) |
| Trial ID | NCT06601842 on ClinicalTrials.gov |
What this trial studies
This pilot study aims to establish a process for monitoring intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in patients who have experienced cardiac arrest. It will analyze the correlation between direct and non-invasive ICP monitoring indicators and develop protocols for managing elevated ICP and insufficient CPP. The study will also focus on personalizing CPP and mean arterial pressure (MAP) optimization to improve neuroprognosis in these patients. Participants will receive ICP monitoring within 12 hours after regaining spontaneous circulation if they meet the inclusion criteria.
Who should consider this trial
Good fit: Ideal candidates include non-traumatic cardiac arrest patients admitted to the ICU with a Glasgow Coma Scale (GCS) motor score of 5 or less.
Not a fit: Patients with traumatic cardiac arrest, pregnancy, or severe pre-existing conditions such as intracranial hemorrhage or coagulopathy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved outcomes and neuroprotection for patients recovering from cardiac arrest.
How similar studies have performed: While direct ICP monitoring in cardiac arrest patients is not routinely practiced, the study's approach is innovative and may provide new insights into post-arrest care.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * non-traumatic cardiac arrest * admitted to ICU * GCS: motor \<=5 * severity: TIMECARD score medium-risk group Exclusion Criteria: * traumatic cardiac arrest * pregnancy * intracranial hemorrhage * coagulopathy * anti-platelet or anti-coagulation use * terminal illness * pre-arrest CPC score \>=3 * GWR \< 1.2 on CT or severe hypoxic ischemic encephalopathy * CNS infection
Where this trial is running
Taipei
- National Taiwan University Hospital — Taipei, Taiwan (RECRUITING)
Study contacts
- Study coordinator: Dean-An Ling, MD
- Email: speckle0714@gmail.com
- Phone: +886-02-23123456
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiac Arrest, cardiac arrest, post-arrest care, ICP monitor, Cerebral perfusion pressure