Immune cell protection after cardiac arrest
Official title: Protective adaptive immune mechanisms after cardiac arrest
Funded at Mainehealth · NIH-11251567 · Data updated 2026-11-12
This project looks at whether immune cells that produce adenosine can calm inflammation and help people recover after cardiac arrest.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mainehealth NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | April 2, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $638,127 |
| NIH project number | 5R01HL173118-03 |
| Project ID | NIH-11251567 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for future translation would be people who have survived cardiac arrest and are recovering from heart or brain injury.
✕Less likely to help
People who did not have a cardiac arrest or whose problems are caused by non-inflammatory conditions are unlikely to benefit from this approach.
What this research studies
After a cardiac arrest, many people develop widespread inflammation that can harm the heart and brain. The team found in patients that higher numbers of CD73-expressing lymphocytes were linked with better outcomes and is using mouse models to study how those cells work. They will test giving protective CD73 immune cells after resuscitation in mice, examine how these lymphocytes form complexes with monocytes to create anti-inflammatory macrophages, and define the molecular steps involved. The aim is to learn whether boosting these cells could be developed into treatments for people who survive cardiac arrest.
Why it matters
Potential benefit: If successful, this work could point to new therapies that reduce damaging inflammation and improve heart and brain recovery after cardiac arrest.
How similar studies have gone: Past studies link CD73 and adenosine to reduced inflammation, but using CD73-expressing immune cells as a therapy after cardiac arrest is a novel and early approach.
Where this research is happening
-
Mainehealth
Portland, United States Active
Researchers
- Principal investigator: Ryzhov, Sergey — Mainehealth
- Study coordinator: Ryzhov, Sergey
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
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Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
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Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
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Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
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Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
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Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.