Immune cell protection after cardiac arrest
Protective adaptive immune mechanisms after cardiac arrest
This project looks at whether immune cells that produce adenosine can calm inflammation and help people recover after cardiac arrest.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mainehealth NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11251567 on NIH RePORTER |
What this research studies
After a cardiac arrest, many people develop widespread inflammation that can harm the heart and brain. The team found in patients that higher numbers of CD73-expressing lymphocytes were linked with better outcomes and is using mouse models to study how those cells work. They will test giving protective CD73 immune cells after resuscitation in mice, examine how these lymphocytes form complexes with monocytes to create anti-inflammatory macrophages, and define the molecular steps involved. The aim is to learn whether boosting these cells could be developed into treatments for people who survive cardiac arrest.
Who could benefit from this research
Good fit: Ideal candidates for future translation would be people who have survived cardiac arrest and are recovering from heart or brain injury.
Not a fit: People who did not have a cardiac arrest or whose problems are caused by non-inflammatory conditions are unlikely to benefit from this approach.
Why it matters
Potential benefit: If successful, this work could point to new therapies that reduce damaging inflammation and improve heart and brain recovery after cardiac arrest.
How similar studies have performed: Past studies link CD73 and adenosine to reduced inflammation, but using CD73-expressing immune cells as a therapy after cardiac arrest is a novel and early approach.
Where this research is happening
Portland, United States
- Mainehealth — Portland, United States (Active)
Researchers
- Principal investigator: Ryzhov, Sergey — Mainehealth
- Study coordinator: Ryzhov, Sergey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.