Testing earlier amiodarone administration in cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot trial aims to evaluate whether administering the initial dose of amiodarone two minutes earlier than current guidelines during out-of-hospital cardiac arrest improves patient outcomes. The study will compare this modified treatment algorithm against usual care for patients experiencing refractory ventricular fibrillation or ventricular tachycardia. Key outcomes include the time to amiodarone delivery, survival rates, and neurological status at hospital discharge. The trial employs a pragmatic stepped-wedge cluster randomized design to assess the effectiveness of the intervention in real-world settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest
* Initial rhythm on EMS rhythm assessment of ventricular fibrillation or ventricular tachycardia
* Recurrence or persistence of ventricular fibrillation or ventricular tachycardia after one defibrillation attempt

Exclusion Criteria:

* Known allergy to amiodarone
* EMS-assessed contraindication to amiodarone
* Pre-existing "do-not-attempt-resuscitation" orders
* Inter-facility transportations
* Initial care by a non-participating EMS agency able to perform advanced life support interventions
* Pediatric patient as determined by EMS
* Prisoners
* Pregnant patients

Where it's running

• Oregon Health & Sciences University
  Portland, Oregon, United States Recruiting

Study contacts

• Principal investigator: Joshua Lupton, MD, MPH — Oregon Health and Science University
• Study coordinator: Joshua Lupton, MD, MPH
• Email: lupton@ohsu.edu
• Phone: (503) 418-6706

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.