A New Treatment for Brain Inflammation After Cardiac Arrest
Official title: A Novel Therapeutic Strategy Targeting Neuroinflammation for Global Cerebral Ischemia Associated with Cardiac Arrest
Funded at Creighton University · NIH-11162443 · Data updated 2026-11-12
This project looks for new ways to protect the brain and improve memory after someone experiences a cardiac arrest.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Creighton University NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $426,656 |
| NIH project number | 5R01NS134993-02 |
| Project ID | NIH-11162443 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is not currently recruiting patients, but future clinical applications would likely target individuals who have experienced global cerebral ischemia following cardiac arrest.
✕Less likely to help
Patients would not receive direct benefit from participating in this early-stage laboratory research.
What this research studies
After a cardiac arrest, many people experience brain damage and memory problems, even after their heart function is restored. This research explores why certain brain cells die after oxygen deprivation, focusing on the role of brain inflammation. Scientists are looking at a specific protein called TREM1, which seems to worsen this inflammation and damage to the memory-forming parts of the brain. The hope is to develop a new treatment that can block TREM1, protecting brain cells and helping people recover better.
Why it matters
Potential benefit: If successful, this work could lead to new medications that protect the brain from damage and improve cognitive function for people who survive cardiac arrest.
How similar studies have gone: While TREM1 has been linked to inflammation in other conditions, its specific role and therapeutic targeting in brain damage after cardiac arrest are novel and currently being explored.
Where this research is happening
-
Creighton University
Omaha, United States Active
Researchers
- Principal investigator: Hwang, Jee-Yeon — Creighton University
- Study coordinator: Hwang, Jee-Yeon
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
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Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
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Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
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Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
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Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
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Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.