A New Treatment for Brain Inflammation After Cardiac Arrest
A Novel Therapeutic Strategy Targeting Neuroinflammation for Global Cerebral Ischemia Associated with Cardiac Arrest
This project looks for new ways to protect the brain and improve memory after someone experiences a cardiac arrest.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Creighton University NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11162443 on NIH RePORTER |
What this research studies
After a cardiac arrest, many people experience brain damage and memory problems, even after their heart function is restored. This research explores why certain brain cells die after oxygen deprivation, focusing on the role of brain inflammation. Scientists are looking at a specific protein called TREM1, which seems to worsen this inflammation and damage to the memory-forming parts of the brain. The hope is to develop a new treatment that can block TREM1, protecting brain cells and helping people recover better.
Who could benefit from this research
Good fit: This foundational research is not currently recruiting patients, but future clinical applications would likely target individuals who have experienced global cerebral ischemia following cardiac arrest.
Not a fit: Patients would not receive direct benefit from participating in this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new medications that protect the brain from damage and improve cognitive function for people who survive cardiac arrest.
How similar studies have performed: While TREM1 has been linked to inflammation in other conditions, its specific role and therapeutic targeting in brain damage after cardiac arrest are novel and currently being explored.
Where this research is happening
Omaha, United States
- Creighton University — Omaha, United States (Active)
Researchers
- Principal investigator: Hwang, Jee-Yeon — Creighton University
- Study coordinator: Hwang, Jee-Yeon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.