Pediatric cooling duration to improve brain outcomes after cardiac arrest
Official title: 2/2 Pediatric Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
Funded at Medical University of South Carolina · NIH-11420478 · Data updated 2026-11-12
This project tests whether different durations of cooling after a child’s cardiac arrest can lead to better brain recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | September 15, 2021 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $666,661 |
| NIH project number | 5U24HL159132-06 |
| Project ID | NIH-11420478 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children who have survived out-of-hospital cardiac arrest and are candidates for targeted temperature management.
✕Less likely to help
Children who do not receive cooling or who have contraindications to cooling may not benefit.
What this research studies
In children who survive out-of-hospital cardiac arrest, brain injury is a major concern. The study looks at how long to apply therapeutic cooling and whether a longer duration helps kids recover neurologically. Researchers will use standardized behavioral assessments to measure outcomes over time and determine a possible dose-response relationship for cooling duration. The goal is to find a cooling strategy that improves survival quality and daily functioning for pediatric patients. Results could guide future clinical practice and improve long-term brain health for affected children.
Why it matters
Potential benefit: If successful, the research could lead to optimized cooling protocols that improve neurologic outcomes for children after cardiac arrest.
How similar studies have gone: Prior studies suggest cooling duration can influence brain protection, but optimal dosing in children remains uncertain.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Yeatts, Sharon Dziuba — Medical University of South Carolina
- Study coordinator: Yeatts, Sharon Dziuba
Related research
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
-
Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
-
Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
-
Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.