Investigating left ventricle unloading during extracorporeal life support
A Multicentric Left Ventricular Venting Strategy Comparison in Patients Receiving Venoarterial Extracorporeal Life Support
This study looks at how different methods of relieving pressure on the heart can help patients on a special life support system called VA ECLS, especially those in serious heart trouble.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 1 Day to 80 Years |
| Sex | All |
| Sponsor | Maastricht University Medical Center Academic / other |
| Locations | 1 site (Maastricht) |
| Trial ID | NCT06766006 on ClinicalTrials.gov |
What this trial studies
This international multicentric observational study aims to collect and analyze clinical data from patients undergoing veno-arterial extracorporeal life support (VA ECLS) in various ICUs. The focus is on understanding left ventricular (LV) overload during VA ECLS and exploring different strategies for LV unloading. By comparing these strategies, the study seeks to determine their efficacy and impact on patient outcomes. The research addresses a critical issue in managing cardiogenic shock and cardiac arrest, which are associated with high mortality rates.
Who should consider this trial
Good fit: Ideal candidates for this study are patients who are undergoing veno-arterial extracorporeal life support.
Not a fit: Patients who are not receiving VA ECMO will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for managing patients with cardiogenic shock and cardiac arrest, potentially enhancing recovery and survival rates.
How similar studies have performed: While there is growing experience with extracorporeal life support, the specific focus on left ventricular unloading strategies during VA ECLS is still a matter of ongoing investigation, indicating a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients undergoing VA ECLS will be enrolled. Exclusion Criteria: * Patients without VA ECMO will not be considered
Where this trial is running
Maastricht
- Maastricht UMC — Maastricht, Netherlands (Recruiting)
Study contacts
- Study coordinator: Paolo Meani, MD, PhD
- Email: paolo.meani@mumc.nl
- Phone: 43 38811067
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.