Mitochondrial DNA differences linked to sudden cardiac arrest risk and recovery

Who could benefit from this research

What this research studies

From a patient's point of view, researchers will compare mitochondrial DNA amount and quality (including copy number, haplotypes, and somatic mutations called heteroplasmy) using blood or tissue samples from people who have had cardiac arrest and matched controls. They will apply a new computational tool to precisely measure mitochondrial mutations and link those findings to medical records about heart disease, ventricular fibrillation, and survival after resuscitation. The team will look for mitochondrial markers that predict who is more likely to have a sudden cardiac arrest and who is more likely to suffer severe heart or brain injury after resuscitation. Results could help guide prevention efforts or identify biological targets to improve survival and recovery.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Arking, Dan E — Johns Hopkins University
• Study coordinator: Arking, Dan E

Related research

Other NIH-funded projects on the same topics.

• Investigating how mitochondrial genetics affect the risk of sudden cardiac arrest and resuscitation outcomes.

  This study is looking at how changes in mitochondrial DNA might affect the risk of sudden cardiac arrest and how well people respond to resuscitation, with the goal of finding new ways to help improve survival rates and create personalized treatments for patients.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11074680

• Using artificial intelligence to assess genetic risk for sudden cardiac arrest through ECG analysis

  This study is looking at how artificial intelligence can help doctors read heart tests (ECGs) to find out if someone has a genetic risk for sudden cardiac arrest, especially for people who might not have easy access to regular genetic testing.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10998172

• Investigating how second-generation antipsychotic medications may lead to sudden cardiac arrest.

  This study is looking at how certain antipsychotic medications might affect heart health in people with schizophrenia and other mental health conditions, so doctors can better understand which medication combinations are safe and help keep patients healthy.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10842279

• Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes

  A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11630823

• Specialized post-arrest care after cardiac arrest

  A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11627883

• Reduce bias in predicting brain recovery after cardiac arrest

  This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.

  NIH research Boston Medical Center · Boston, United States · NIH-11468065

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.