How long cooling helps children after cardiac arrest
Official title: 1/2 Pediatric Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
Funded at University of Michigan at Ann Arbor · NIH-11173673 · Data updated 2026-11-12
This research sees if longer targeted cooling after an out-of-hospital cardiac arrest helps children survive and recover brain function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 15, 2021 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $4,201,827 |
| NIH project number | 5UH3HL159134-05 |
| Project ID | NIH-11173673 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children (infants through adolescents) who are successfully resuscitated after an out-of-hospital cardiac arrest and admitted to a participating hospital for targeted temperature management are the intended candidates.
✕Less likely to help
Patients who were not resuscitated, who have already severe irreversible brain injury, or who cannot receive cooling for medical reasons are unlikely to benefit from this intervention.
What this research studies
If my child is resuscitated after an out-of-hospital cardiac arrest, this project would compare different lengths of targeted temperature management (therapeutic cooling) to see which duration leads to better brain recovery. Doctors will use controlled cooling (typical therapeutic hypothermia ranges) in pediatric ICU settings and follow children through recovery. Outcomes will include survival and neurologic function measured with tools like the Vineland Adaptive Behavior Scales–Third Edition. The goal is to define a duration-response relationship so more children can get the right 'dose' of cooling.
Why it matters
Potential benefit: If successful, identifying the best cooling duration could improve survival and long-term brain function for children after cardiac arrest.
How similar studies have gone: Adult trials of targeted temperature management have shown mixed results and pediatric data are limited, so this approach builds on promising preclinical work but is still relatively novel for children.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Moler, Frank W — University of Michigan at Ann Arbor
- Study coordinator: Moler, Frank W
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
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Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
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Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
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Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
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Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
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Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.