Continuous jugular venous oxygen saturation monitoring after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults who achieve return of spontaneous circulation but remain comatose after cardiac arrest will undergo placement of a PediaSat oximetry catheter in the jugular vein to measure jugular venous oxygen saturation (SjO2). Some patients will have continuous SjO2 monitoring while others will have intermittent blood-sample-based measurements using the same catheter and hospital blood gas analysis. This observational protocol will record SjO2 trends alongside standard neurocritical care measures such as targeted temperature management, blood pressure, oxygenation, carbon dioxide targets, and EEG monitoring. The goal is to characterize between-patient heterogeneity in brain oxygen delivery after cardiac arrest to inform potential individualized neuroprotective treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

• Adults (\>=18 years old) resuscitated from out-of-hospital or in-hospital cardiac arrest who remain comatose (motor Glasgow coma scale \<=4) for at least 30 minutes when examined off sedation/neuromuscular blockade.

Exclusion Criteria:

* Cardiac arrest due to traumatic brain injury, intracranial bleeding, or ischemic stroke
* Cervical spine fracture
* Need for immediate prone positioning for severe hypoxemic respiratory failure
* Marked hemodynamic instability precluding priority of any neuromonitoring (multiple recurrent cardiac arrests, norepinephrine equivalents \> 1.5 mcg/kg/min)
* Moribund neurological status based upon initial clinical, radiographic and historical assessment (e.g. diffuse cerebral edema or herniation on head computed tomography)
* Pregnancy
* Prisoners

Where it's running

• UPMC Presbyterian Hospital
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Byron Drumheller, MD — University of Pittsburgh
• Study coordinator: Byron Drumheller, MD
• Email: drumhellerbc@upmc.edu
• Phone: 1-301-461-9301

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.