Clinical trial Recruiting at 4 sites Observational Ages 18 and up

Assessing brain injury in cardiac arrest patients

Official title: Early and Objective Assessment of Neurological Prognosis in Cardiac Arrest Patients

Run by Nantes University Hospital · NCT06387225 · Data updated 2026-11-12

This study is trying to find a better way to check for brain injuries in patients who have had a cardiac arrest to help decide who needs special treatments to improve their recovery.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment608 (estimated)
SponsorNantes University Hospital
Academic / other
Locations4 sites (La Roche-sur-Yon and 3 other locations)
StatusRecruiting
StartedFebruary 2, 2025
Main results expectedMay 31, 2027
Study endsMay 31, 2027
Registry record updatedFebruary 26, 2025
Trial IDNCT06387225 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who are comatose upon admission to intensive care following an out-of-hospital cardiac arrest.

Probably not a fit

Patients who experience in-hospital cardiac arrest or are under 18 years of age may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on the early and objective assessment of neurological prognosis in patients who have suffered out-of-hospital cardiac arrest and are admitted to intensive care. It aims to identify cerebral lesions that could indicate the need for neuroprotective interventions, which are crucial for improving patient outcomes. By utilizing various assessment tools, the study seeks to establish a precise and reproducible method for evaluating the severity of brain injuries upon admission. This approach could help prioritize treatment for patients with significant neurological damage while avoiding unnecessary interventions for those without such lesions.

Why it matters

Potential benefit: If successful, this study could lead to more targeted and effective neuroprotective treatments for cardiac arrest patients, potentially improving survival and recovery rates.

How similar studies have gone: While there is limited research in this specific area, the study's focus on early neurological assessment in cardiac arrest patients is a novel approach that could fill an important gap in current medical knowledge.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥ 18 years
* Admitted to intensive care with out-of-hospital cardiac arrest
* Comatose on admission (defined by a Glasgow score ≤ 8)
* Informed relative who has consented to the patient's participation in the study or inclusion under emergency procedure if the relative is absent at the time of inclusion

Exclusion Criteria:

* In-hospital cardiac arrest
* Age \< 18 years
* Person under guardianship or legal protection
* Prior inclusion in the study

Where it's running

  • CHD Vendée
    La Roche-sur-Yon, France
    Recruiting
  • CHU Nantes
    Nantes, France
    Recruiting
  • APHP - Hôpital Cochin
    Paris, France
    Recruiting
  • CH Saint-Nazaire
    Saint-Nazaire, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.