Butylphthalide for improving brain function after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the neuroprotective effects of butylphthalide in patients who have experienced cardiac arrest. It is a multicenter, prospective randomized controlled trial designed to assess both near-term and long-term neurological outcomes in patients with severe brain injury following resuscitation. Participants will receive either butylphthalide or a saline solution, and their neurological function will be evaluated using internationally accepted assessment methods. The goal is to find effective treatments to enhance recovery and improve prognosis for these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18-80 years old.
2. Glasgow Coma Scale (GCS) scores ≤8 upon admission.
3. Return of Spontaneous Circulation (ROSC) ≥30min.
4. Signed the informed consent form.

Exclusion Criteria:

1. Cardiac arrest due to irreversible causes such as trauma, poisoning, etc.
2. Cardiac arrest due to end-stage conditions such as advanced cancer.
3. Persistent cardiogenic shock that is unreversed (defined as a systolic blood pressure persistently \<90mmHg despite treatment with fluid resuscitation, vasopressor agents, and inotropic medications).
4. Presence of pre-existing cerebrovascular disease prior to cardiac arrest or confirmed intracranial hemorrhage by CT scan following admission.
5. Pre-existing CPC scores of 3-5 prior to cardiac arrest.
6. Prior use of NBP or any medication containing NBP before cardiac arrest.
7. Presence of severe hepatic or renal dysfunction before cardiac arrest (defined as ≥3× upper limit of normal alanine transaminase or ≥2× upper limit of normal creatinine).
8. Bradycardia or sick sinus syndrome occurs after ROSC.
9. History of prior drug or food allergies, or known allergies to the medication components used in this study.
10. Existence of treatment limitations (patient or their legal representative refusing advanced life support treatment, including mechanical ventilation, chest compressions, targeted temperature management, etc.).
11. Presence of severe bleeding tendency upon admission.
12. Body temperature \<30℃ upon admission.
13. Pregnant or lactating women, or reproductive-age females with elevated serum human Chorionic Gonadotropin (hCG) levels.
14. Other conditions deemed unsuitable for this trial by the principal investigator.

Where it's running

• Beijing Chao-Yang Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Ziren Tang, Ph.D
• Email: tangziren1970@163.com
• Phone: +86 010-85231530

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating Butylphthalide for Neurological Recovery After Cardiac Arrest

  This study is testing if a medication called Butylphthalide can help improve brain function in people who have survived a cardiac arrest.

  Recruiting Phase 4 Capital Medical University · Beijing, Beijing Municipality · NCT06353334

• Heartsight helps caregivers of kids after cardiac arrest manage uncertainty and fear

  This pilot trial tests if the Heartsight information program is acceptable and helpful for caregivers of children who recently had a cardiac arrest.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT07707037

• Brain blood flow and brain regulation in critically ill kids

  This study tests how blood flow in the brain behaves in critically ill children using a noninvasive ultrasound (TCD) to see if brain autoregulation patterns relate to outcomes.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07613918

• Cardiopulmonary resuscitation with balloon occlusion of the descending aorta for hospitalized patients

  This trial will test whether adding a balloon occlusion of the descending aorta (REBOA) to standard ACLS helps people having an in-hospital cardiac arrest regain and keep a pulse.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT07434726

• Digital serious game to improve critical care nurses' targeted temperature management skills and situational awareness.

  We will test whether adding a digital serious game to regular lectures helps adult ICU nurses learn targeted temperature management and improve situational awareness.

  Recruiting National Taiwan University Hospital · Taipei, Taipei · NCT07239206

• Plasma proteins, metabolites, and platelet changes in extracorporeal CPR for cardiac arrest patients

  This project will test whether patterns in blood proteins, small molecules, and platelet shape changes can help identify which adults with cardiac arrest might benefit from extracorporeal CPR.

  Recruiting Central China Fuwai Hospital of Zhengzhou University · Zhengzhou, Henan · NCT07113769

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.