Targeting brain inflammation after global brain injury from cardiac arrest
Official title: A Novel Therapeutic Strategy Targeting Neuroinflammation for Global Cerebral Ischemia Associated with Cardiac Arrest
Funded at Creighton University · NIH-11365149 · Data updated 2026-11-12
This grant tests a new treatment aimed at reducing brain inflammation after cardiac arrest to protect memory and thinking in people who survive a cardiac arrest.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Creighton University NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $426,656 |
| NIH project number | 5R01NS134993-03 |
| Project ID | NIH-11365149 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals who have survived cardiac arrest with global cerebral ischemia and are at risk of cognitive impairment.
✕Less likely to help
Patients without evidence of hippocampal injury or those not at risk for neuroinflammation may derive less benefit.
What this research studies
If the brain doesn’t get oxygen during cardiac arrest, patients can have lasting memory and thinking problems. The researchers plan to study how dampening a specific inflammatory pathway (TREM1) may prevent nerve cells in a key brain area from dying and improve cognitive outcomes after the event. They will use RNA analysis and animal models to understand how this therapy changes brain gene activity and inflammation. The goal is to develop a treatment that works alongside emergency care to limit brain injury.
Why it matters
Potential benefit: If successful, this approach could reduce cognitive disabilities after cardiac arrest and improve survivors’ quality of life.
How similar studies have gone: Prior work suggests targeting neuroinflammation can modulate brain injury after ischemia, but this specific TREM1 pathway approach is exploratory.
Where this research is happening
-
Creighton University
Omaha, United States Active
Researchers
- Principal investigator: Hwang, Jee-Yeon — Creighton University
- Study coordinator: Hwang, Jee-Yeon
Related research
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Reducing biased predictions of brain recovery after cardiac arrest
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.