Using intravenous oxygen to treat cardiac arrest
Intravenous oxygen for the treatment of cardiac arrest
This study is testing a new way to deliver oxygen directly into the bloodstream during cardiac arrest, which could help patients who are struggling to breathe, using tiny bubbles that release oxygen safely when injected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11104567 on NIH RePORTER |
What this research studies
This research investigates a novel approach to improve oxygen delivery during cardiac arrest by using a new gas carrier that allows for safe intravenous injection of oxygen. The method involves pH-responsive polymeric microbubbles that release oxygen directly into the bloodstream, potentially overcoming the limitations of traditional ventilation methods. By focusing on patients experiencing asphyxia cardiac arrest, the study aims to enhance oxygenation during critical moments of resuscitation. The research will be conducted using a swine model to evaluate the effectiveness of this innovative treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced cardiac arrest, particularly those with asphyxia as the underlying cause.
Not a fit: Patients who have cardiac arrest due to non-asphyxia causes may not benefit from this specific treatment approach.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and neurological outcomes for patients experiencing cardiac arrest.
How similar studies have performed: While the approach of using intravenous oxygen delivery is innovative, similar methods have shown promise in preliminary studies, indicating potential for success.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Peng, Yifeng — Boston Children's Hospital
- Study coordinator: Peng, Yifeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.