Using intravenous oxygen to treat cardiac arrest
Official title: Intravenous oxygen for the treatment of cardiac arrest
Funded at Boston Children's Hospital · NIH-11104567 · Data updated 2026-11-12
This study is testing a new way to deliver oxygen directly into the bloodstream during cardiac arrest, which could help patients who are struggling to breathe, using tiny bubbles that release oxygen safely when injected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 21, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $889,188 |
| NIH project number | 1R01HL178815-01 |
| Project ID | NIH-11104567 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced cardiac arrest, particularly those with asphyxia as the underlying cause.
✕Less likely to help
Patients who have cardiac arrest due to non-asphyxia causes may not benefit from this specific treatment approach.
What this research studies
This research investigates a novel approach to improve oxygen delivery during cardiac arrest by using a new gas carrier that allows for safe intravenous injection of oxygen. The method involves pH-responsive polymeric microbubbles that release oxygen directly into the bloodstream, potentially overcoming the limitations of traditional ventilation methods. By focusing on patients experiencing asphyxia cardiac arrest, the study aims to enhance oxygenation during critical moments of resuscitation. The research will be conducted using a swine model to evaluate the effectiveness of this innovative treatment.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and neurological outcomes for patients experiencing cardiac arrest.
How similar studies have gone: While the approach of using intravenous oxygen delivery is innovative, similar methods have shown promise in preliminary studies, indicating potential for success.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Peng, Yifeng — Boston Children's Hospital
- Study coordinator: Peng, Yifeng
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
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Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
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Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
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Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.