Intravenous oxygen for cardiac arrest
Intravenous oxygen for the treatment of cardiac arrest
This project tests whether tiny oxygen-filled particles given through a vein can quickly raise oxygen levels during cardiac arrest to help people survive and reduce brain injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11333296 on NIH RePORTER |
What this research studies
If someone has cardiac arrest, researchers are developing tiny oxygen-filled particles that can be injected into a vein to deliver oxygen directly into the bloodstream. The particles are pH-sensitive polymer microbubbles that hold a high concentration of oxygen and are designed to dissolve safely after releasing their gas. In realistic pig models of asphyxia cardiac arrest, small doses of these microbubbles improved oxygenation during resuscitation, and the team will refine dosing and safety. The goal is to advance the approach toward use in hospitals and emergency care for people who cannot be oxygenated by standard methods.
Who could benefit from this research
Good fit: Ideal candidates would be people experiencing in-hospital or out-of-hospital cardiac arrest, particularly when conventional ventilation fails to restore oxygen levels.
Not a fit: Patients whose cardiac arrest is not driven by severe hypoxemia or who are beyond the time window for effective resuscitation may not receive benefit from this therapy.
Why it matters
Potential benefit: If successful, this approach could rapidly boost oxygen during cardiac arrest, improving chances of survival and reducing neurologic damage.
How similar studies have performed: This is a novel delivery method: preclinical animal studies (swine) showed improved oxygenation with these microbubbles, but human use remains largely untested.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Peng, Yifeng — Boston Children's Hospital
- Study coordinator: Peng, Yifeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.