Comparing two CPR methods for out-of-hospital cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effectiveness of Chest Compression Only CPR (CO-CPR) versus Standard CPR (S-CPR) in cases of out-of-hospital cardiac arrest (OHCA). It is a multicenter, randomized, open-label trial where bystanders trained in CPR will receive dispatcher instructions to perform either CO-CPR or S-CPR. The primary goal is to determine if CO-CPR is non-inferior to S-CPR in terms of survival rates. The study aims to enhance bystander CPR rates and improve outcomes for patients experiencing OHCA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Unconsciousness with no, abnormal or agonal breathing (suspected OHCA)
* The suspected OHCA is witnessed (seen or heard)
* Any Bystander at the scene has previous training in CPR

Exclusion Criteria:

* Age below 18 years
* Collapse is not witnessed
* Bystander has no prior CPR training
* Obvious asphyxia (i.e. hanging, foreign body, suffocation, strangulation)
* Obvious drug overdose / intoxication
* Pregnancy
* Trauma (penetrating, blunt, burn injury)

Post randomisation exclusion Criteria from data analysis:

* Not EMS-verified cardiac arrest
* Previous do not resuscitate (DNR) decision

Where it's running

• AREU, Agenzia Regionale Emergenza Urgenza
  Bergamo, Italy Recruiting
• SOS Alarm AB
  Stockholm, Sweden Recruiting

Study contacts

• Principal investigator: Jacob Hollenberg, MD, PhD — Karolinska Institutet
• Study coordinator: Jacob Hollenberg, MD. PhD
• Email: jacob.hollenberg@ki.se
• Phone: 004686163816

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Innovative technologies to improve cardiac arrest resuscitation effectiveness

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• Rehabilitation program for survivors of out-of-hospital cardiac arrest

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  Recruiting Phase 4 Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT05173740

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.