Comparing two CPR methods for out-of-hospital cardiac arrest
A Randomized Trial Comparing Survival After of a Simplified Form of Cardiopulmonary Resuscitation (CPR) Consisting of Compressions Only Compared to CPR With Compressions and Rescue Breaths
This study is testing whether Chest Compression Only CPR is just as effective as Standard CPR for helping people who have a cardiac arrest outside of the hospital.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 3260 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 2 sites (Bergamo and 1 other locations) |
| Trial ID | NCT03981107 on ClinicalTrials.gov |
What this trial studies
This trial investigates the effectiveness of Chest Compression Only CPR (CO-CPR) versus Standard CPR (S-CPR) in cases of out-of-hospital cardiac arrest (OHCA). It is a multicenter, randomized, open-label trial where bystanders trained in CPR will receive dispatcher instructions to perform either CO-CPR or S-CPR. The primary goal is to determine if CO-CPR is non-inferior to S-CPR in terms of survival rates. The study aims to enhance bystander CPR rates and improve outcomes for patients experiencing OHCA.
Who should consider this trial
Good fit: Ideal candidates are adults who are unconscious with no or abnormal breathing, and whose cardiac arrest is witnessed by a bystander trained in CPR.
Not a fit: Patients who are under 18 years old, have asphyxia-related cardiac arrest, or have not been trained in CPR may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to increased survival rates for patients experiencing out-of-hospital cardiac arrest.
How similar studies have performed: Previous studies have shown promising results for CO-CPR, suggesting it may be as effective as traditional CPR in certain scenarios.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Unconsciousness with no, abnormal or agonal breathing (suspected OHCA) * The suspected OHCA is witnessed (seen or heard) * Any Bystander at the scene has previous training in CPR Exclusion Criteria: * Age below 18 years * Collapse is not witnessed * Bystander has no prior CPR training * Obvious asphyxia (i.e. hanging, foreign body, suffocation, strangulation) * Obvious drug overdose / intoxication * Pregnancy * Trauma (penetrating, blunt, burn injury) Post randomisation exclusion Criteria from data analysis: * Not EMS-verified cardiac arrest * Previous do not resuscitate (DNR) decision
Where this trial is running
Bergamo and 1 other locations
- AREU, Agenzia Regionale Emergenza Urgenza — Bergamo, Italy (Recruiting)
- SOS Alarm AB — Stockholm, Sweden (Recruiting)
Study contacts
- Principal investigator: Jacob Hollenberg, MD, PhD — Karolinska Institutet
- Study coordinator: Jacob Hollenberg, MD. PhD
- Email: jacob.hollenberg@ki.se
- Phone: 004686163816
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.