Condition

Acute Heart Failure clinical trials and research

• 25Clinical trials
• 7NIH research projects
• 35Countries

Newest Acute Heart Failure clinical trials

All recruiting trials (25)

• Infusion of furosemide to see if a loading infusion helps remove fluid better in acute heart failure

  This study tests whether giving furosemide as a continuous infusion with a loading dose is better at removing excess fluid than giving it as bolus injections in adults with acute heart failure.

  Recruiting Phase 4 University of Aarhus · Randers · NCT07577596

• Characterizing phenotypes of acute heart failure

  This project will try to see if heart function measures, imaging features (radiomics), and blood biomarkers can predict outcomes for adults hospitalized with acute heart failure, including cardiogenic shock.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT07508891

• Early finerenone treatment for hospitalized adults with acute heart failure and LVEF ≥40%

  This trial will test whether starting finerenone early during hospitalization helps adults with acute heart failure who have a left ventricular ejection fraction of 40% or higher.

  Recruiting at 13 sites Phase 4 Juntendo University · Handa, Aichi-ken and 20 other locations · NCT07397650

• Intensive GDMT optimization for women after heart failure hospitalization

  This study tests whether rapidly increasing and closely monitoring heart failure meds in women after hospitalization can reduce death or readmission within a year.

  Recruiting Phase 4 IRCCS Policlinico S. Donato · San Donato Milanese, MILANO and 11 other locations · NCT07295522

• Using intra‑abdominal pressure and bedside ultrasound to guide decongestive treatment in heart failure

  This trial will test whether using bladder pressure (intra‑abdominal pressure) measurements together with bedside ultrasound to guide IV loop diuretics helps people hospitalized with acute heart failure get rid of excess fluid more effectively than usual care.

  Recruiting Phase 3 Instituto de Investigación Sanitaria Aragón · Zaragoza and 1 other locations · NCT07008365

• Investigating heart issues in COPD patients during hospital stays

  This study is trying to see if sudden worsening of COPD can cause heart problems in hospitalized patients and how it affects their recovery.

  Recruiting Sahlgrenska University Hospital · Gothenburg, Region Västra Götaland · NCT06597331

• Congestion profiles in adults hospitalized with acute heart failure

  This project will see if different congestion types in adults hospitalized with acute heart failure predict response to IV loop diuretics and risks of rehospitalization or death.

  Recruiting University Medical Center Groningen · Groningen · NCT06587854

• Using lung ultrasound to guide treatment for acute heart failure

  This study is testing if using lung ultrasound to guide treatment can help adults with acute heart failure leave the hospital sooner and feel better compared to standard care.

  Recruiting at 4 sites University Hospital, Geneva · Geneva, Canton of Geneva and 4 other locations · NCT06465498

• Finding the best diuretic treatment for acute heart failure with fluid overload

  This study is testing whether adding Metolazone or Acetazolamide to standard diuretic treatment can help adults with acute heart failure and fluid overload feel better and spend more days out of the hospital.

  Recruiting at 5 sites Phase 3 Copenhagen University Hospital, Hvidovre · Hvidovre, Capital Region of Denmark and 5 other locations · NCT06166654

• Registry of patients with acute cardiovascular diseases in Naples

  This study looks at how patients with serious heart problems are treated and what happens to them while they are in the hospital and after they go home.

  Recruiting Federico II University · Naples · NCT06162247

• Evaluating Finerenone for Heart Failure Patients

  This study is testing if a medication called finerenone can help hospitalized patients with heart failure feel better and live longer compared to a placebo.

  Recruiting at 348 sites Phase 3 Colorado Prevention Center · Birmingham, Alabama and 355 other locations · NCT06008197

• Effects of Ferric Derisomaltose on Exercise and Quality of Life in Heart Failure Patients

  This study is testing if adding Ferric Derisomaltose to regular treatment can help people with heart failure and low iron feel better and exercise more easily.

  Recruiting Phase 4 China-Japan Friendship Hospital · Beijing, Chaoyang District · NCT05991128

• Effects of Ferric Derisomaltose on Exercise Capacity and Quality of Life in Heart Failure Patients

  This study is testing if adding Ferric Derisomaltose to regular treatment can help people with heart failure and low iron feel better and exercise more easily.

  Recruiting Phase 4 China-Japan Friendship Hospital · Beijing, Beijing Municipality · NCT05971732

• Early treatment with empagliflozin for high-risk acute heart failure patients

  This study is testing if giving a new heart medication called empagliflozin early can help high-risk patients with acute heart failure feel better after being hospitalized.

  Recruiting at 64 sites Phase 3 Juntendo University · Anjo, Aichi-ken and 68 other locations · NCT05392764

• Optimizing treatment for pulmonary edema and heart failure

  This study is testing which treatment works best for people with acute heart failure and pulmonary edema by comparing a diuretic, a vasodilator, and a combination of both.

  Recruiting at 4 sites Phase 4 Copenhagen University Hospital, Rigshospitalet · Copenhagen, Copenhagen and 4 other locations · NCT05276219

• Evaluating congestion markers in patients with acute heart failure

  This study is trying to find out if certain tests done on patients with acute heart failure before they leave the hospital can help predict their risk of dying or being readmitted within three months.

  Recruiting Central Hospital, Nancy, France · Vandœuvre-lès-Nancy · NCT04343443

• Evaluating congestion markers in patients with acute heart failure and preserved ejection fraction

  This study is trying to find out if certain tests can help predict the risk of death or being readmitted to the hospital for patients with acute heart failure who have preserved heart function.

  Recruiting Central Hospital, Nancy, France · Vandœuvre-lès-Nancy · NCT04343430

• Evaluating congestion in patients with acute heart failure at discharge

  This study is testing new ways to check for fluid buildup in the lungs of patients with acute heart failure when they leave the hospital to see if it can help them recover better.

  Recruiting Central Hospital, Nancy, France · Vandœuvre-lès-Nancy · NCT04332692

• Nationwide registry of patients with acute heart failure in Korea

  This study is collecting information from hospitalized adults with acute heart failure in Korea to see how different factors affect their treatment and recovery.

  Recruiting Seoul National University Bundang Hospital · Seongnam · NCT04329234

• Identifying triggers and progression of heart failure

  This study looks at patients with heart failure to see what causes it and how it gets worse, while also testing if digoxin can help those whose heart failure is triggered by fast heartbeats.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT04000061

• Using MRI to measure lung fluid in patients with acute heart failure

  This study is testing if using MRI can help measure lung fluid in people with acute heart failure to see if it can improve treatment and predict their chances of coming back to the hospital or facing serious issues later on.

  Recruiting University of Alberta · Edmonton, Alberta and 1 other locations · NCT03999138

• Short- and long-term outlook after emergency admission for acute heart failure

  This project will try to see how people admitted to the emergency department with acute heart failure do at 30 days and one year, comparing those with reduced versus preserved ejection fraction.

  Recruiting University of Monastir · Monastir, Monastir Governorate · NCT03806972

• Registry of patients needing ECMO in Australia and New Zealand

  This study is creating a detailed database of patients in Australia and New Zealand who need ECMO for serious heart or lung problems to help improve treatment and outcomes for critically ill patients.

  Recruiting at 28 sites Australian and New Zealand Intensive Care Research Centre · Canberra, Australian Capital Territory and 28 other locations · NCT03793257

• Continuous versus intermittent IV furosemide for acute heart failure

  This trial tests whether giving furosemide as a continuous IV infusion or as intermittent IV boluses works better for adults hospitalized with acute decompensated heart failure.

  Recruiting at 4 sites University of Siena · Chioggia, Venezia and 3 other locations · NCT02638142

• Registry for patients with acute heart failure

  This study is creating a registry of people hospitalized for acute heart failure to learn more about their symptoms and health conditions, which could help improve treatment and care for future patients.

  Recruiting University Hospital, Geneva · Geneva · NCT02444416

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using AI to monitor lung fluid in sudden (acute) heart failure in the ER

  This project will use an AI-assisted lung ultrasound method to track lung congestion in people who come to the emergency department with acute heart failure.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11267990

• Stepwise water‑pill (diuretic) plan versus usual care for people with acute heart failure in the emergency room

  This project compares a step-by-step plan for giving water pills to usual care to help people with sudden worsening heart failure in the emergency room remove extra fluid and feel better sooner.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11171538

• Using AI to monitor fluid buildup in patients with acute heart failure in emergency settings

  This study is looking at how using a special ultrasound tool can help doctors better check for fluid buildup in the lungs of patients with acute heart failure in emergency rooms, so they can get the right treatment faster and leave the hospital feeling better.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11048481

• Improving hospitalization decisions for emergency patients with heart failure

  This study is looking at how to help doctors decide if patients with acute heart failure should be admitted to the hospital or can safely recover at home, by considering important factors about their health and personal situations.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11013391

• Understanding changes in kidney function during acute heart failure

  This study is looking into how heart failure affects kidney function, especially in veterans, to find specific markers that can help doctors understand the different reasons for kidney problems during heart failure, ultimately aiming to improve diagnosis and treatment for patients.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-10975923

• Comparing two approaches to diuretic therapy for patients with acute heart failure in the emergency department

  This study is looking at whether a special plan for using diuretics can help people with acute heart failure feel better and recover faster in the emergency department compared to the usual care they receive.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10907749

• Improving how we diagnose acute heart failure

  This study is working on a new way to help doctors more accurately diagnose acute heart failure in patients who come to the emergency room with symptoms like shortness of breath, so they can get the right treatment faster and feel better sooner.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10821378

Related topics

Quick answers

How many Acute Heart Failure clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 35 countries. The most sites are in Italy (4 trials), Denmark (3 trials), France (3 trials), Switzerland (3 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 6, Phase 3: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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