How the immune system calms inflammation after cardiac arrest
Resolution of inflammation after cardiac arrest
Researchers are exploring how immune cells and signals calm inflammation after out-of-hospital cardiac arrest to protect the brain and improve recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11251192 on NIH RePORTER |
What this research studies
If you or a loved one survives an out-of-hospital cardiac arrest, this project uses blood samples collected soon after resuscitation to study immune cells. Scientists apply single-cell techniques to a biobank of preserved blood immune cells (PBMCs) from patients to map which cell types and signals are linked to good or bad neurological outcomes. They follow up key findings with lab tests on patient cells and experiments in animal models to test pathways such as Nectin-2 and IFNγ that control monocyte–NK cell interactions. The aim is to discover immune mechanisms that could be targeted to reduce brain injury and improve survival after cardiac arrest.
Who could benefit from this research
Good fit: Ideal participants are adults treated for out-of-hospital cardiac arrest at participating hospitals who can have blood samples collected shortly after resuscitation.
Not a fit: People without recent cardiac arrest or those too medically unstable to provide consent or blood samples are unlikely to take part or directly benefit.
Why it matters
Potential benefit: Could identify immune targets that lead to treatments reducing brain injury and improving survival after cardiac arrest.
How similar studies have performed: Preliminary human blood analyses and mouse experiments suggest targeting IFNγ and related immune pathways can reduce neurological injury, but applying single-cell human biobank data to guide therapies is relatively new.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kim, Edy Yong — Brigham and Women's Hospital
- Study coordinator: Kim, Edy Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.