Investigating inflammation and metabolism after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the molecular mechanisms behind the systemic inflammatory response and metabolic changes following cardiac arrest. By analyzing blood samples from patients over a week, the study will assess how these factors relate to brain injury, survival rates, and functional outcomes. The research focuses on the role of immune cell activity and the presence of brown adipose tissue in influencing recovery and neurological outcomes. The goal is to identify potential therapeutic targets that could improve recovery after cardiac arrest.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 years or older
* Admitted to the intensive care unit after cardiac arrest episode
* Unresponsive after resuscitation

Exclusion Criteria:

* Moribund / actively dying at the time of evaluation
* Informed consent cannot be obtained within 24 hours of resuscitation
* Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion

Where it's running

• Maine Medical Center
  Portland, Maine, United States Recruiting

Study contacts

• Principal investigator: Sergey Ryzhov, MD, PhD — MaineHealth Institute for Research
• Study coordinator: David B Seder, MD
• Email: david.seder@mainehealth.org
• Phone: 207-662-2179

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.