Improving survival rates for cardiac arrest patients with Pulseless Electrical Activity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the outcomes of patients experiencing Pulseless Electrical Activity (PEA) during cardiac arrest, focusing on the effectiveness of a High Calcium, Low Sodium (HCLS) fluid compared to a High Calcium, High Sodium (HCHS) fluid in pre-hospital care. Conducted by the Carilion Clinic and Virginia Tech Carilion School of Medicine, the study will automatically enroll eligible PEA patients treated by local emergency medical services. Patients will be randomized into two groups to receive either HCLS or HCHS fluids, with both groups receiving calcium. The goal is to determine if the HCLS fluid improves survival chances for these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients who present with PEA at any time during the patients' treatment by Roanoke Fire-EMS, Botetourt County Department of Fire \& EMS and/or Salem Fire-EMS. This study defines a PEA presentation as any patient who is unconscious, presenting without a carotid pulse and with non-(VT/VF) ventricular tachycardia/ventricular fibrillation electrical activity.

Exclusion Criteria:

* Patient less than 18 years old
* Known pregnancy
* Duration of untreated cardiac arrest of more than 30 minutes
* Traumatic cardiac arrest
* Known (LVAD) Left Ventricular Assist Device
* Rapidly fatal underlying disease
* Known or suspected digitalis toxicity
* A physical, durable (DNR) Do Not Resuscitate (or durable DNR medical jewelry) presented to EMS before treatment with asserting a preference not to be enrolled
* Prisoners and other populations with involuntary consent

Where it's running

• Carilion Clinic
  Roanoke, Virginia, United States Recruiting

Study contacts

• Principal investigator: Carol Bernier, DO — Virginia Polytechnic Institute and State University
• Study coordinator: Cara Spivy, MS
• Email: crspivey@carilionclinic.org
• Phone: 540-676-7965

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.