Using vasopressin and steroids with adrenaline for cardiac arrest treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of adding vasopressin and methylprednisolone to standard adrenaline treatment in patients experiencing in-hospital cardiac arrest. It is a randomized, placebo-controlled, double-blind study involving approximately 1400 participants over a projected period of 3-4 years. Eligible patients are those who meet the criteria for adrenaline administration according to current guidelines. The trial aims to determine if this combination can improve survival rates from 9% to 14%. Informed consent will be obtained from patients or their representatives post-resuscitation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hospitalized men \> 18 years and hospitalized women \> 50 years.

Exclusion Criteria:

* Patients not capable to comprehend information to decide about participation in the study
* Women considered of childbearing potential (WOCBP) i. e. premenopausal women
* Patients with do not resuscitate (DNR) descision
* Prior enrollment and randomization in the trial

Where it's running

• Sahlgrenska University Hospital
  Gothenburg, Sweden Recruiting
• Tiohundra
  Norrtälje, Sweden Recruiting

Study contacts

• Principal investigator: Sune Forsberg, MD, PhD — Tiohundra AB
• Study coordinator: Sune Forsberg, MD, PhD
• Email: sune.forsberg@tiohundra.se
• Phone: +46722037953

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• International registry for pediatric in-hospital cardiac arrest outcomes

  This study is creating a global registry to track the outcomes of children who have cardiac arrests in hospitals, to see how well they survive and recover after treatment.

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• Heartsight helps caregivers of kids after cardiac arrest manage uncertainty and fear

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• Cardiopulmonary resuscitation with balloon occlusion of the descending aorta for hospitalized patients

  This trial will test whether adding a balloon occlusion of the descending aorta (REBOA) to standard ACLS helps people having an in-hospital cardiac arrest regain and keep a pulse.

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• How bed height affects chest compression quality and rescuer posture during pediatric CPR simulation

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• Digital serious game to improve critical care nurses' targeted temperature management skills and situational awareness.

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  Recruiting National Taiwan University Hospital · Taipei, Taipei · NCT07239206

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.