Condition

Acute Ischemic Stroke clinical trials and research

• 141Clinical trials
• 31NIH research projects
• 4New in 30 days
• 41Countries

Newest Acute Ischemic Stroke clinical trials

All recruiting trials (141)

• Short-Term outside-in nerve stimulation for acute ischemic stroke

  This trial tests whether a 5-day external trigeminal nerve stimulation given after stroke can help more patients recover better than a sham treatment.

  Recruiting Xidian University · Xi'an · NCT07911605

• Sevoflurane vs. Propofol for anesthesia in stroke patients undergoing clot-removal

  This study tests whether sevoflurane or propofol used for anesthesia during endovascular treatment of an acute ischemic stroke affects the final brain damage and recovery.

  Recruiting Phase 3 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona · NCT07902791

• Safety of adding NRICM301 to standard care for adults with acute ischemic stroke

  This study tests whether adding NRICM301, a traditional Chinese medicine formula, to usual care is safe for adults with acute ischemic stroke.

  Recruiting En Chu Kong Hospital · New Taipei City · NCT07900503

• Intracranial Recanalization with LT3001 in Acute Ischemic Stroke

  This phase II study tests whether LT3001 given to adults with acute ischemic stroke can help reopen blocked brain arteries.

  Recruiting Phase 2 Lumosa Therapeutics Co., Ltd. · Taichung · NCT07890298

• Mobilisation After Endovascular Stroke Treatment

  This study checks whether moving around 12 hours after endovascular stroke treatment is as safe as moving around 24 hours for people with an acute ischemic stroke.

  Recruiting at 2 sites Karolinska Institutet · Tampere and 1 other locations · NCT07860333

• Endovascular therapy plus standard care vs standard care alone for distal and medium vessel strokes

  In people with acute ischemic stroke due to distal or medium vessel blockages, this study tests whether adding endovascular treatment to the usual medical care helps improve outcomes compared with medical care alone.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Barcelona · NCT07843797

• Acute Ischemic Stroke in People with Active Cancer

  This study looks at how often people with active cancer have another ischemic stroke after an initial event, to see what factors might be linked to a recurrence.

  Recruiting Osaka University · Suita, Osaka · NCT07819526

• Anisodine hydrobromide added to standard care for acute ischemic stroke patients undergoing thrombectomy

  In people with acute ischemic stroke who are getting endovascular treatment, this study tests whether anisodine hydrobromide plus standard care helps more than standard care plus a placebo.

  Recruiting at 12 sites Phase 2 Capital Medical University · Anyang and 12 other locations · NCT07800572

• Prourokinase plus standard care vs standard care alone in mid- vessel stroke 4.5–24 hours after onset

  This trial tests whether intravenous recombinant human prourokinase can improve outcomes for adults with acute medium vessel occlusion stroke when given 4.5 to 24 hours after onset.

  Recruiting Phase 3 The First Affiliated Hospital of Anhui Medical University · Hefei, Anhui · NCT07776873

• FORWARD: Functional Outcomes in Real-World Treatment and Revascularization of Non-dominant and Distal M2 Occlusions

  This study tests how the Penumbra System works in real-world patients with non-dominant or distal M2 occlusions who have an acute ischemic stroke, comparing endovascular thrombectomy to medical management alone.

  Recruiting at 7 sites Penumbra Inc. · Englewood, Colorado and 6 other locations · NCT07749170

• Tenecteplase or Reteplase Bridging Before Thrombectomy in Acute Ischemic Stroke

  This trial tests whether giving tenecteplase or reteplase before mechanical thrombectomy helps people with acute ischemic stroke due to large vessel occlusion, compared with doing thrombectomy alone.

  Recruiting Phase 3 Beijing Tiantan Hospital · Beijing, Beijing Municipality and 4 other locations · NCT07748039

• Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke

  This study tests whether cerebral autoregulation monitoring during thrombectomy can predict futile recanalization and bad outcomes in adults with acute ischemic stroke.

  Recruiting at 4 sites Beijing Shijitan Hospital, Capital Medical University · Beijing and 3 other locations · NCT07747701

• HRS-4029 for Acute Ischemic Stroke: Is It Safe and Helpful

  This trial tests whether HRS-4029 given within 3 hours of stroke onset helps people with acute ischemic stroke compared with a placebo.

  Recruiting Phase 2 Beijing Suncadia Pharmaceuticals Co., Ltd · Beijing, Beijing Municipality · NCT07739160

• Early Identification of BAD-related Stroke in Adults

  This study tests how well a multisource AI diagnostic approach can identify BAD-related stroke among adults with acute ischemic stroke within a week of onset.

  Recruiting at 11 sites Peking Union Medical College Hospital · Beijing and 10 other locations · NCT07693816

• Early VR-Based Rehab for the Arm After Acute Ischemic Stroke

  This trial tests whether starting virtual reality–based arm rehabilitation within 24 hours of an acute ischemic stroke helps improve arm strength, thinking skills, anxiety, and confidence to exercise compared with standard rehab.

  Recruiting Tri-Service General Hospital (TSGH) · Taipei · NCT07674329

• Endovascular Therapy for Basilar Artery Occlusion With Large Ischemic Core

  This trial tests whether adding endovascular therapy to standard medical care helps people with acute basilar artery occlusion and a large area of brain already affected.

  Recruiting The First Affiliated Hospital of University of Science and Technology of China · Hefei, Anhui · NCT07672795

• How well stroke patients move early after a severe stroke using a wearable

  This study tests how adults with severe acute ischemic stroke move during their hospital stay by wearing a small activity monitor to see early mobility patterns.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT07638462

• Placental-derived 3D mesenchymal stem cells for acute ischemic stroke

  A Phase 1/2a trial tests whether a single intravenous dose of human placenta-derived 3D mesenchymal stem cells can be given safely to adults who recently had an ischemic stroke and whether it shows early signs of benefit.

  Recruiting Phase 1/2 Chinese PLA General Hospital · Beijing · NCT07635758

• BDNF Levels and Cardioembolic Stroke in Ischemic Stroke Patients

  This study tests whether blood levels of brain-derived neurotrophic factor (BDNF) relate to cardioembolic stroke risk in people who have had an acute ischemic stroke.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT07624396

• TNK for Acute Ischemic Stroke in the Extended Time Window with Simple Imaging

  This trial tests whether giving a single IV bolus of tenecteplase helps people with acute ischemic stroke 4.5 to 24 hours after onset, selected using a simple non-contrast CT scan.

  Recruiting Phase 3 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou · NCT07606807

• Real-world use of Medtronic Neurovascular devices for acute ischemic stroke

  This registry tests how Medtronic Neurovascular devices perform in everyday treatment of acute ischemic stroke, across multiple centers and patients.

  Recruiting at 3 sites Medtronic Neurovascular Clinical Affairs · Flint, Michigan and 2 other locations · NCT07599904

• Rapid local brain-protecting postconditioning after thrombectomy for acute stroke

  This trial tests a quick post-surgery step after clot removal to see if it helps people recover better after a severe stroke caused by a large vessel blockage.

  Recruiting Shanghai Jiao Tong University Affiliated Sixth People's Hospital · Shanghai · NCT07598799

• Minocycline after successful recanalization in acute anterior circulation stroke

  This trial tests whether adding minocycline after a successful endovascular thrombectomy helps people recover better after an acute anterior circulation stroke.

  Recruiting Phase 2/3 Tongji Hospital · Wuhan, Hubei · NCT07594314

• Minocycline after successful reopening of posterior circulation stroke with endovascular therapy

  This trial tests whether adding minocycline after successful thrombectomy helps people recover better from a posterior circulation stroke.

  Recruiting Phase 2/3 Tongji Hospital · Wuhan, Hubei · NCT07594301

• QD202 for acute ischemic stroke patients treated with clot‑busting therapy (no thrombectomy)

  This study will test whether giving the drug QD202 by IV infusion after clot‑busting (thrombolysis) helps adults with acute ischemic stroke who are not having a thrombectomy.

  Recruiting at 14 sites Phase 2 Shanghai QuietD Biotechnology Co., Ltd. · Meizhou, Guangdong and 13 other locations · NCT07581210

• Ultra-early detection of failed recovery after stroke using cerebral autoregulation during thrombectomy

  This study tests whether monitoring how the brain controls blood flow during thrombectomy can quickly show which large-vessel ischemic stroke patients are unlikely to regain function after a successful vessel reopening.

  Recruiting at 3 sites Beijing Shijitan Hospital, Capital Medical University · Beijing, Beijing Municipality and 3 other locations · NCT07556068

• Aspiration with a super large bore catheter vs. stent retriever in anterior circulation large vessel occlusion

  This trial tests whether using a super large bore catheter for suction works better or worse than using a stent retriever to remove a clot in adults with a major stroke in the front part of the brain.

  Recruiting Shanghai Jiao Tong University Affiliated Sixth People's Hospital · Shanghai · NCT07555977

• Sivelestat added to endovascular clot retrieval for acute anterior circulation stroke

  This study tests whether giving sivelestat sodium alongside mechanical thrombectomy helps improve outcomes for adults with acute ischemic stroke due to large vessel occlusion.

  Recruiting at 2 sites Xuanwu Hospital, Beijing · Weifang, Shandong and 1 other locations · NCT07552610

• Repeated intravenous prourokinase for ischemic stroke with medium to large vessel occlusion within 4.5 hours

  This study tests whether giving an extra infusion of prourokinase after initial treatment helps restore blood flow in adults with acute ischemic stroke due to medium or large vessel blockages within 4.5 hours.

  Recruiting Phase 2 General Hospital of Shenyang Military Region · Shenyang, None Selected · NCT07550296

• Early evolocumab plus statin for large-artery ischemic stroke

  This will test whether giving evolocumab with a statin soon after a large-artery ischemic stroke helps people recover better than a statin alone.

  Recruiting First Affiliated Hospital of Harbin Medical University · Heilongjiang · NCT07540741

• Tenecteplase for late-window stroke guided by DWI-FLAIR mismatch

  This study tests whether giving tenecteplase 4.5–9 hours after stroke onset can improve outcomes for patients with MRI showing DWI-FLAIR mismatch.

  Recruiting Phase 3 The First Affiliated Hospital of Zhengzhou University · Zhengzhou, Henan · NCT07540416

• GM1 added to mechanical thrombectomy for large vessel stroke

  This trial tests whether giving GM1 after mechanical thrombectomy can help improve recovery for adults with acute anterior circulation large vessel stroke.

  Recruiting at 2 sites Phase 4 Xuanwu Hospital, Beijing · Beijing, Beijing Municipality and 1 other locations · NCT07519044

• Tenecteplase after non-contrast CT for unknown-onset stroke

  This study tests whether giving tenecteplase helps people with acute ischemic stroke whose onset time is unknown.

  Recruiting Phase 3 First Affiliated Hospital of Guangxi Medical University · Xiamen, Fujian and 14 other locations · NCT07475949

• Intravenous Tenecteplase in Very Old Adults with Acute Ischemic Stroke

  This study tests whether giving tenecteplase through a vein within 4.5 hours of stroke onset helps people 80 and older.

  Recruiting First Affiliated Hospital of Guangxi Medical University · Nanning, Guangxi · NCT07475936

• SUMMIT RISE: Route 92 mechanical reperfusion for acute ischemic stroke

  This will test the Route 92 mechanical reperfusion system to see if it helps restore blood flow and improve recovery in adults treated for acute ischemic stroke who received the device as the first pass during thrombectomy.

  Recruiting Phase 4 Route 92 Medical, Inc. · West Jordan, Utah · NCT07436156

• J147 in Acute Ischemic Stroke after Mechanical Thrombectomy

  This study tests whether injecting J147 helps people who had an ischemic stroke and underwent clot removal to see if outcomes improve and how safe the drug is.

  Recruiting Phase 2 Abrexa Pharmaceuticals, Inc. · Long Beach, California and 4 other locations · NCT07430917

• Non-invasive vagus nerve stimulation to lower inflammation and brain injury markers after acute ischemic stroke

  This test tries whether adding non-invasive vagus nerve stimulation to usual care lowers inflammation and blood markers of brain injury in adults with acute ischemic stroke from a large vessel occlusion.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07404852

• QHRD106 injection to treat acute ischemic stroke

  This study will test whether QHRD106 injections given within 24 hours can help adults with acute ischemic stroke who are not receiving reperfusion therapy.

  Recruiting Phase 2 Changzhou Qianhong Bio-pharma Co., Ltd. · Nanjing, Jiangsu · NCT07396337

• TAK-755 to treat acute ischemic stroke in adults

  This will test a single dose of TAK-755 versus placebo to see if it is safe and helps adults who had an acute ischemic stroke within 24 hours.

  Recruiting at 13 sites Phase 2 Takeda · Scottsdale, Arizona and 59 other locations · NCT07392450

• rhPro-UK before endovascular stroke treatment in the extended window

  In adults with acute ischemic stroke due to a large vessel blockage, this trial tests whether giving rhPro-UK before thrombectomy in the 4.5–24 hour window helps people recover better than a placebo.

  Recruiting at 10 sites Phase 3 First Affiliated Hospital Xi'an Jiaotong University · Lanzhou, Gansu and 9 other locations · NCT07389460

• Testing B2065 for safety and early effectiveness in acute ischemic stroke

  This will test a single IV infusion of B2065 versus placebo in adults 18–75 who have an acute ischemic stroke and can be treated within 36 hours of symptom onset.

  Recruiting Phase 1/2 Tasly Pharmaceutical Group Co., Ltd · Beijing · NCT07371624

• Tenecteplase to help recovery after an ischemic stroke more than 4.5 hours after last seen well

  This trial will test whether a single IV dose of tenecteplase helps adults who had an ischemic stroke (including wake-up strokes) recover when treatment starts more than 4.5 hours after they were last seen well.

  Recruiting at 198 sites Phase 3 Boehringer Ingelheim · Buenos Aires and 257 other locations · NCT07361302

• Endovascular Rescue with Stenting for Large Vessel Occlusion after Partial Clot Removal

  This trial tests whether adding a stent to the artery after a mechanical thrombectomy helps patients with large vessel stroke who still have significant narrowing in the artery.

  Recruiting Phase 3 ProMedica Health System · Toledo, Ohio · NCT07356284

• Endovascular treatment for acute ischemic stroke caused by M2 segment blockage

  This trial will test whether endovascular therapy helps adults (18–84) who have an acute ischemic stroke from a blockage in the M2 segment of the middle cerebral artery.

  Recruiting at 3 sites Hyogo Medical University · Nishinomiya, Hyōgo and 2 other locations · NCT07347665

• BALANCE: Concurrent thrombolysis for AIS with elevated pre-treatment BP

  In people having an acute ischemic stroke with high blood pressure, the BALANCE trial tests whether starting thrombolysis at the same time as BP-lowering treatment is safe and effective enough to consider it instead of waiting for BP to drop first.

  Recruiting West China Hospital · Chengdu, Sichuan and 1 other locations · NCT07318948

• Remote telemedicine support for acute ischemic stroke care at smaller hospitals

  This project will try remote telemedicine support to help adults who arrive within 4.5 hours of an acute ischemic stroke get faster, standardized care at smaller hospitals.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT07302971

• Intra-arterial tenecteplase for medium-vessel occlusion stroke

  This trial will test whether delivering tenecteplase directly into the blocked medium brain artery helps adults with medium-vessel ischemic stroke recover better when treated within 24 hours of symptom onset.

  Recruiting Phase 2/3 Tongji Hospital · Wuhan, Hubei · NCT07302854

• IV thrombolysis for branch atheromatous stroke in deep brain arteries

  This study looks at whether intravenous thrombolysis can help people with branch atheromatous disease-related stroke compared with standard antiplatelet therapies.

  Recruiting at 6 sites Sigmund Freud PrivatUniversitat · Vienna, State of Vienna and 7 other locations · NCT07299994

• Adding intravenous tirofiban after clot-busting treatment for patients who don't improve quickly from acute ischemic stroke

  This trial will test whether giving the IV medicine tirofiban after standard clot-busting treatment helps adults with acute ischemic stroke who show poor improvement within an hour.

  Recruiting Phase 4 Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT07290751

• KPCXM18 injection for acute ischemic stroke.

  This trial will try different doses of the KPCXM18 injection to see if it helps adults who have had an acute ischemic stroke when started within 12 hours of symptom onset.

  Recruiting at 23 sites Phase 2 Kunming Pharmaceuticals, Inc. · Beijing, Beijing Municipality and 22 other locations · NCT07279493

• Blood pressure management during early clot‑busting treatment for acute ischemic stroke

  This trial will test whether an adjusted blood pressure approach is safer than usual care for people with acute ischemic stroke who are receiving IV thrombolysis and have high blood pressure.

  Recruiting Phase 2 Shanghai East Hospital · Shanghai · NCT07279259

• Albumin plus endovascular therapy for anterior large-vessel ischemic stroke

  This trial will try adding albumin to endovascular treatment to see if it helps adults (18–80) with anterior large-vessel ischemic stroke treated within 24 hours.

  Recruiting at 61 sites Phase 3 Capital Medical University · Anqing, Anhui and 60 other locations · NCT07263308

• Tenecteplase before transfer for anterior circulation large-vessel stroke (4.5–24 hours)

  This will test whether a single bolus of tenecteplase given at the first hospital before transfer helps people with anterior circulation large-vessel ischemic stroke who present 4.5–24 hours after they were last well.

  Recruiting at 2 sites Phase 3 Xuanwu Hospital, Beijing · Beijing, Beijing Municipality and 1 other locations · NCT07253181

• SHPL-49 injection for treating acute ischemic stroke (Phase III)

  This trial tests whether a seven-day course of intravenous SHPL-49 helps adults with acute ischemic stroke who receive thrombolysis within eight hours of symptom onset.

  Recruiting Phase 3 Shanghai Hutchison Pharmaceuticals Limited · Linfen, Shanxi · NCT07241520

• Tenecteplase before transfer for basilar artery stroke 4.5–24 hours after symptom onset

  This trial tests whether giving IV tenecteplase before transfer helps people with basilar artery occlusion who are 4.5–24 hours from symptom onset and are being sent for thrombectomy.

  Recruiting Phase 4 Xuanwu Hospital, Beijing · Beijing · NCT07203625

• rhTNK-tPA for large-vessel ischemic stroke treated 4.5–24 hours after last seen normal

  This study will try whether a single IV dose of rhTNK-tPA helps adults with large-vessel ischemic stroke who present 4.5 to 24 hours after they were last seen normal, compared with a placebo.

  Recruiting Phase 3 CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd. · Puyang, Henan · NCT07201688

• CONDA stent retriever for reopening large-vessel blockages in acute ischemic stroke.

  The CONDA stent retriever will be tried to reopen blocked large brain arteries in adults with acute ischemic stroke treated within 24 hours of symptom onset.

  Recruiting Anaconda Biomed S.L. · Budapest and 1 other locations · NCT07174505

• Methylprednisolone given into the artery and IV after thrombectomy for anterior large-vessel stroke

  This trial tests whether giving intra-arterial methylprednisolone immediately after a successful thrombectomy followed by three days of IV methylprednisolone helps people with acute anterior large-vessel ischemic stroke recover better.

  Recruiting Phase 3 Tang-Du Hospital · Xi'an, Shaanxi · NCT07141303

• Adding intra-arterial clot-busting therapy to endovascular treatment for medium-vessel stroke

  It tests whether adding intra-arterial clot-busting medicine to endovascular treatment helps adults with medium-vessel acute ischemic stroke who can be treated within 24 hours recover better.

  Recruiting Phase 3 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07137832

• Thrombectomy plus medical care versus medical care alone for large-vessel ischemic stroke 24–72 hours after last known well

  This will see if adding endovascular thrombectomy to usual medical care helps adults with a large-vessel ischemic stroke who arrive 24–72 hours after they were last known to be well.

  Recruiting at 6 sites University Hospitals Cleveland Medical Center · Chicago, Illinois and 5 other locations · NCT07115940

• Dual Stentriever Approach in Acute Ischemic Stroke with Large Vessel Occlusion

  This study tests whether using two stentrievers together helps people with a large vessel stroke in the front part of the brain.

  Recruiting at 4 sites Instituto de Investigación Marqués de Valdecilla · Burgos and 3 other locations · NCT07113184

• Tenecteplase for Posterior Circulation Stroke Between 4.5 and 24 Hours

  This trial tests whether giving tenecteplase through an IV helps people with acute posterior circulation stroke who are between 4.5 and 24 hours from onset.

  Recruiting The First Affiliated Hospital of University of Science and Technology of China · Hefei · NCT07094763

• Tenecteplase IV thrombolysis for acute ischemic stroke after recent DOAC use

  This will test whether a single IV dose of tenecteplase can improve 90-day recovery in adults who have an acute ischemic stroke and took a direct oral anticoagulant within the past 48 hours.

  Recruiting Phase 3 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07092709

• Hyperbaric oxygen after stroke thrombectomy in acute ischemic stroke patients

  This trial tests whether giving hyperbaric oxygen after endovascular stroke treatment helps improve outcomes in patients with acute ischemic stroke.

  Recruiting Beijing Chao Yang Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07049692

• Weight-adjusted urokinase dosing for early ischemic stroke

  This research will try different weight-based doses of intravenous urokinase given within 6 hours to find a safe, effective dosing plan for adults with acute ischemic stroke.

  Recruiting at 2 sites Capital Medical University · Beijing, Beijing Municipality and 1 other locations · NCT07047326

• Balloon angioplasty vs stenting after residual intracranial narrowing in acute ischemic stroke

  This trial tests whether balloon angioplasty is as good as stenting for patients with residual intracranial narrowing after initial stroke treatment.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT07026331

• Endovascular treatment plus tirofiban for strokes from intracranial atherosclerosis

  This trial will see if giving tirofiban after endovascular clot removal helps people with acute large-vessel ischemic stroke caused by intracranial atherosclerosis.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT07026318

• Tenecteplase for ischemic stroke given after 4.5 hours when CT shows a small infarct

  This trial will try whether a single 0.25 mg/kg dose of tenecteplase helps adults with anterior-circulation ischemic stroke who present more than 4.5 hours after last known well and whose non-contrast CT shows limited infarction.

  Recruiting Phase 3 Huashan Hospital · Shanghai, Shanghai Municipality and 1 other locations · NCT06994975

• Improving outcomes for patients with acute ischemic stroke using JX10

  This study is testing if a new treatment called JX10 can help people who have had an acute ischemic stroke feel better and recover more functionally compared to a placebo.

  Recruiting at 104 sites Phase 2/3 Corxel Pharmaceuticals · Long Beach, California and 103 other locations · NCT06990867

• Using EEG to Distinguish Between Types of Stroke

  This study is testing if brain activity measured by EEG can help doctors tell the difference between two types of strokes and predict how well patients will recover.

  Recruiting Assiut University · Asyut, Asyut Governorate · NCT06984965

• Biobank for patients with large vessel occlusion stroke

  This study is collecting blood and clot samples from patients with large vessel occlusion strokes to see if analyzing them can help improve diagnosis and treatment for these patients.

  Recruiting at 4 sites First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui and 4 other locations · NCT06963489

• Intra-Arterial Magnesium Therapy After Mechanical Thrombectomy for Acute Ischemic Stroke

  This phase I study tests whether injecting magnesium sulfate directly into brain arteries after mechanical clot removal is safe for people with acute ischemic stroke.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT06956521

• Comparing 5G Mobile Stroke Units to Standard Emergency Services for Stroke Treatment

  This study is testing whether using 5G Mobile Stroke Units can help stroke patients get better treatment compared to regular emergency services.

  Recruiting Beijing Emergency Medical Center · Beijing, Beijing Municipality · NCT06943885

• Angong Niuhuang pills with different bovine bezoar sources for acute ischemic stroke

  This will try two commercially made Angong Niuhuang pill formulations to see if they help adults with recent acute ischemic stroke recover better and reduce inflammation.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT06883110

• Evaluating heart health in patients with acute ischemic stroke receiving reperfusion therapy

  This study looks at how heart problems affect people who have had an acute ischemic stroke and are receiving treatment to see if it can help improve their care and outcomes.

  Recruiting Soochow University · Suzhou, Jiangsu · NCT06882577

• Using BASIS technique for treating acute large vessel occlusion strokes

  This study is testing a new method called BASIS to see if it can safely help people with severe strokes caused by blocked blood vessels in the brain recover better.

  Recruiting Fujian Medical University Union Hospital · Fuzhou, Fujian · NCT06881420

• Thrombolysis for stroke patients on Factor Xa inhibitors

  This study is testing if a common stroke treatment can safely help patients who have taken certain blood thinners in the last two days.

  Recruiting at 21 sites Phase 3 Oslo University Hospital · Aalborg, Aalborg and 20 other locations · NCT06878066

• Qingre Huatan formula to prevent early neurological worsening after acute ischemic stroke

  This study will test whether adding the Qingre Huatan herbal formula to standard care can prevent early neurological worsening in adults who have had an acute ischemic stroke within 48 hours of symptom onset.

  Recruiting Phase 1/2 Dongzhimen Hospital, Beijing · Beijing, Beijing Municipality · NCT06857487

• Using platelet aggregation tests to guide antiplatelet treatment in acute ischemic stroke

  This trial will test whether switching adults with acute ischemic stroke or high-risk TIA who show clopidogrel resistance on platelet testing to ticagrelor reduces repeat strokes and is safe.

  Recruiting Phase 3 Sichuan Provincial People's Hospital · Chengdu, Sichuan · NCT06853535

• AI-guided personalized rehabilitation to improve upper-limb recovery after stroke

  This project tests whether an explainable AI system can predict recovery and recommend tailored rehab (usual care alone or plus acupuncture, robotic training, or NMES) for people aged 65–80 who had a first-time unilateral stroke 1–6 months earlier.

  Recruiting Chinese University of Hong Kong · Hong Kong, Sha Tin · NCT06828679

• Remote ischemic conditioning for adults with moderate acute stroke from large artery narrowing

  This study will test remote ischemic conditioning plus usual medical care versus usual care alone in adults 18–85 who have a moderate acute ischemic stroke caused by large artery atherosclerosis within 48 hours of symptom onset.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT06775782

• Aleeto for moderate to severe acute ischemic stroke

  This trial will test whether Aleeto, given within 72 hours of symptom onset, helps improve neurological recovery in adults with moderate to severe acute ischemic stroke compared with placebo.

  Recruiting Phase 2 Beijing Tiantan Hospital · Beijing · NCT06759753

• Using intravenous thrombolysis for patients on new oral anticoagulants after a stroke

  This study is testing if a common stroke treatment can safely help people who have recently taken new blood thinners after having a stroke.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT06749834

• Using MRI to detect bleeding in plaques for stroke diagnosis

  This study is trying to see if using MRI to find bleeding in artery plaques can help doctors better diagnose strokes, especially in patients who have unexplained strokes.

  Recruiting Ludwig-Maximilians - University of Munich · Munich · NCT06749106

• Brain scans and blood tests to find autonomic (brain–heart) dysfunction after acute ischemic stroke or TIA

  This project will test whether MRI scans and blood tests can detect nerve-control problems that affect heart and blood pressure in adults who recently had an ischemic stroke or a transient ischemic attack.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT06740942

• Evaluating the Ceretrieve Device for Treating Acute Ischemic Stroke

  This study is testing a new device called Ceretrieve to see if it can safely help people with acute ischemic stroke by restoring blood flow to their brains.

  Recruiting Ceretrieve Ltd. · Heidelberg · NCT06733246

• Using Human Urinary Kallidinogenase to Treat Acute Ischemic Stroke

  This study is testing whether a treatment called Human Urinary Kallidin can help reduce inflammation and improve recovery in people who have just had an acute ischemic stroke.

  Recruiting First Affiliated Hospital of Harbin Medical University · Harbin, Heilongjiang · NCT06696703

• Optimizing Blood Pressure Control After Thrombectomy for Stroke

  This study tests whether managing blood pressure more tightly after a stroke treatment helps patients recover better and improves their quality of life.

  Recruiting Phase 3 Yonsei University · Seoul, Seoul · NCT06677970

• Hibernation-like therapy for treating acute ischemic stroke

  This study is testing if a combination of two medications can safely help people who have had a stroke during a specific treatment procedure.

  Recruiting Phase 1 Capital Medical University · Linyi, Shandong · NCT06663631

• Evaluating a new catheter for treating severe strokes

  This study tests if a new type of catheter can help people with severe strokes recover better than the usual treatment.

  Recruiting The First Affiliated Hospital of University of Science and Technology of China · Hefei, Anhui · NCT06559475

• Extending treatment window for stroke patients with medium vessel occlusions

  This study is testing if giving a clot-busting drug to stroke patients with certain types of blockages after the usual treatment time can help them recover better than standard care.

  Recruiting The First Affiliated Hospital of University of Science and Technology of China · Hefei, Anhui · NCT06559436

• Using remote ischemic conditioning to improve outcomes in acute ischemic stroke patients undergoing thrombectomy

  This study tests if a new treatment called remote ischemic conditioning can help stroke patients recover better after a procedure to remove a blood clot.

  Recruiting at 60 sites Phase 3 Capital Medical University · Suzhou, Anhui and 69 other locations · NCT06559241

• Early use of antiplatelet therapy after thrombolysis for stroke

  This study tests if giving aspirin right after stroke treatment can help adults feel better and prevent further problems.

  Recruiting at 106 sites Phase 3 Capital Medical University · Bengbu, Anhui and 118 other locations · NCT06548971

• Assessing treatment strategies for stroke patients with atrial fibrillation

  This study is testing different treatment options for stroke patients with atrial fibrillation to see which one helps them recover better and prevents future strokes.

  Recruiting Jinan Central Hospital · Jinan, Shandong · NCT06548269

• Investigating the role of sTREM in outcomes after thrombectomy for stroke

  This study is trying to see if certain proteins in the blood can help predict how well people recover after a procedure to remove a blood clot from their brain during a stroke.

  Recruiting The Affiliated Hospital of Xuzhou Medical University · Xuzhou, Jiangsu · NCT06545591

• Collecting real-life data on endovascular treatments for brain aneurysms

  This study is collecting real-life information on how safe and effective a specific type of device is for treating brain aneurysms in patients.

  Recruiting Microvention-Terumo, Inc. · Vigo, Pontevedra · NCT06494436

• Evaluating the effects of Calculus Bovis Sativus for ischemic cerebrovascular diseases

  This study is testing whether a traditional Chinese medicine called Calculus Bovis Sativus can help improve brain health and reduce inflammation in people with ischemic cerebrovascular diseases like stroke.

  Recruiting at 2 sites Tongji Hospital · Wuhan, Hubei and 1 other locations · NCT06474507

• Evaluating brain metabolism in minor strokes with large vessel occlusion

  This study is trying to see how brain metabolism changes in people with minor strokes caused by large blood vessel blockages to help predict their recovery and guide treatment.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT06457217

• Weak scalp electrical stimulation to protect the brain after an acute ischemic stroke

  This trial will test whether a weak electrical current applied to the scalp can increase collateral blood flow and protect brain tissue in adults with acute ischemic stroke who are not candidates for clot removal.

  Recruiting at 3 sites Phase 2 University of California, Los Angeles · Los Angeles, California and 2 other locations · NCT06440707

• Treatment for Acute Ischemic Stroke Patients with Thrombolysis

  This study is testing if a new drug called NoNO-42 can help people aged 45 to 90 who are having an acute ischemic stroke and are getting thrombolysis treatment.

  Recruiting at 9 sites Phase 2 NoNO Inc. · Calgary, Alberta and 8 other locations · NCT06403267

• Investigating vessel perforation during thrombectomy for stroke treatment

  This study looks at complications from thrombectomy procedures for stroke, specifically vessel perforations, to see what causes them and how to improve safety and treatment for patients.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT06394180

• Head down tilt to improve blood flow in stroke patients

  This study is testing if tilting stroke patients' heads down can improve blood flow to their brains and help them recover better before they receive treatment.

  Recruiting Phase 2 University of Milano Bicocca · Avezzano and 5 other locations · NCT06297863

• Assessing cognitive impairment in young adults after ischemic stroke

  This study is testing how an ischemic stroke affects thinking and memory in young adults aged 18-45 over time.

  Recruiting Centre Hospitalier Universitaire de Nice · Cannes and 1 other locations · NCT06262529

• Evaluating BB-031 for patients with acute ischemic stroke

  This study is testing a new drug called BB-031 to see if it is safe and helpful for people who have had an acute ischemic stroke within the last 24 hours.

  Recruiting at 19 sites Phase 2 Basking Biosciences, Inc. · Scottsdale, Arizona and 24 other locations · NCT06226805

• Combining Human Urinary Kallidinogenase with Endovascular Therapy for Acute Ischemic Stroke

  This study is testing if adding a new treatment called Human Urinary Kallidinogenase to standard endovascular therapy can help people who have had a severe stroke caused by a blocked blood vessel.

  Recruiting Huashan Hospital · Shanghai · NCT06211712

• Evaluating treatment options for stroke patients presenting after 24 hours

  This study is trying to see if a special procedure or the best medical care can help stroke patients who arrive at the hospital more than 24 hours after their symptoms started.

  Recruiting Tianjin Huanhu Hospital · Tianjin, Tianjin Municipality · NCT06200753

• Comparing Urokinase and Alteplase for Treating Acute Ischemic Stroke

  This study is testing if a cheaper medication called urokinase works as well and is as safe as the more expensive drug alteplase for treating people with acute ischemic stroke.

  Recruiting The First Affiliated Hospital of Zhengzhou University · Lanzhou, Gansu and 15 other locations · NCT06194968

• Comparing regional and general anesthesia for carotid surgery in stroke patients

  This study is testing whether regional anesthesia is safer and more effective than general anesthesia for stroke patients undergoing carotid surgery.

  Recruiting Pirogov Russian National Research Medical University · Moscow · NCT06175715

• Using Hyperbaric Oxygen Therapy for Recovery After Acute Ischemic Stroke

  This study is testing if Hyperbaric Oxygen Therapy can help people recovering from a stroke improve their movement and daily activities while they are in rehab.

  Recruiting LCMC Health · New Orleans, Louisiana · NCT06148285

• Comparing endovascular therapy and best medical treatment for mild acute stroke with large vessel occlusion

  This study is testing whether a special treatment for stroke called endovascular therapy can help people with mild strokes caused by a blocked blood vessel feel better compared to just using standard medical care.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT06143488

• Using umbilical cord stem cells to treat acute ischemic stroke

  This study is testing whether giving umbilical cord stem cells to people who have had an acute ischemic stroke can help them recover better and improve their overall health.

  Recruiting Phase 2/3 Cytopeutics Sdn. Bhd. · Cheras, Kuala Lumpur · NCT06129175

• Observing treatment options for acute ischemic stroke in Southwest China

  This study is tracking 8,000 patients with acute ischemic stroke in Southwest China to see which treatment options work best and how they help people recover over 90 days.

  Recruiting The Affiliated Hospital Of Southwest Medical University · Luzhou · NCT06125236

• Early use of tirofiban after thrombolysis for acute ischemic stroke

  This study is testing if giving tirofiban right after a stroke treatment can help patients recover better and stay safe.

  Recruiting The First Hospital of Jilin University · Changchun, Jilin · NCT06045156

• Testing the RapidPulseTM Aspiration System for treating acute ischemic stroke

  This study is testing a new device called the RapidPulseTM Aspiration System to see if it can safely and effectively help people with acute ischemic stroke caused by blocked blood vessels in the brain.

  Recruiting at 21 sites RapidPulse, Inc · Torrance, California and 29 other locations · NCT06029491

• Prognostic prediction model for patients with acute stroke undergoing endovascular therapy

  This study is trying to create a tool that helps doctors predict how well patients with acute stroke will do after they receive a specific treatment called endovascular therapy.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06009315

• Comparing radial and femoral access for treating acute basilar artery occlusion

  This study is testing whether using a wrist (radial) access instead of a groin (femoral) access for treating a specific type of stroke can lead to better results for patients.

  Recruiting Jinling Hospital, China · Nanjing, Jiangsu · NCT05903560

• Registry for Endovascular Treatment of Acute Ischemic Stroke

  This study is trying to see how safe and effective a specific treatment for stroke is in helping patients recover after a blocked blood vessel.

  Recruiting Changhai Hospital · Shanghai · NCT05864638

• MRI plus tissue analysis to understand clot-related bleeding and microvascular blockage after large sylvian ischemic stroke treated with hemicraniectomy

  This project will test whether special MRI scans combined with small brain tissue samples can better identify clot-related microvessel blockages and bleeding in adults with large sylvian ischemic strokes who need or may need decompressive hemicraniectomy.

  Recruiting Fondation Ophtalmologique Adolphe de Rothschild · Paris · NCT05847699

• Prophylactic Stress Ulcer Drugs and Outcomes After Mechanical Thrombectomy in Acute Ischemic Stroke

  This observational study looks at whether preventive stress ulcer medicines used after mechanical thrombectomy in adults with acute ischemic stroke affect their outcomes.

  Recruiting at 19 sites Nanfang Hospital, Southern Medical University · Fuzhou, Fujian and 18 other locations · NCT05845372

• Evaluating endovascular treatment for acute ischemic stroke caused by carotid artery occlusion

  This study is testing if a new treatment combining a special procedure for blocked arteries with standard care can help people who have had a stroke feel better and recover more fully.

  Recruiting University Hospital, Montpellier · Montpellier, Fance · NCT05832762

• Registry for patients with acute ischemic stroke caused by large or medium vessel occlusion

  This study is creating a registry to track and learn from 50,000 patients with acute ischemic stroke caused by large or medium vessel blockages to see how different treatments work in real life.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT05779215

• Evaluating blood pressure variability in acute ischemic stroke patients

  This study is testing how changes in blood pressure affect recovery and thinking skills in people who have had an acute ischemic stroke.

  Recruiting at 3 sites Yale University · New Haven, Connecticut and 2 other locations · NCT05756257

• Sovateltide treatment for acute ischemic stroke

  This test will try sovateltide in adults aged 18–80 who had an ischemic stroke within 24 hours to see if it helps improve recovery.

  Recruiting at 54 sites Phase 3 Pharmazz, Inc. · Tucson, Arizona and 53 other locations · NCT05691244

• Evaluating LT3001 for treating acute ischemic stroke

  This study is testing if a new drug called LT3001 can help people who have had an acute ischemic stroke feel better and recover more effectively.

  Recruiting at 28 sites Phase 2 Shanghai Pharmaceuticals Holding Co., Ltd · Beijing, Beijing Municipality and 27 other locations · NCT05686642

• Using Semaglutide to reduce damage from acute ischemic stroke

  This study is testing if Semaglutide can help reduce brain damage in people who have had an acute ischemic stroke and had no to moderate disability before the stroke.

  Recruiting Phase 2 University of Aarhus · Aarhus · NCT05630586

• Comparing stenting and non-stenting approaches for acute ischemic stroke treatment

  This study is testing whether adding a stent to a common stroke treatment helps people with acute ischemic stroke from a blocked carotid artery recover better than just using the treatment alone.

  Recruiting at 54 sites Phase 3 Mercy Health Ohio · Mobile, Alabama and 59 other locations · NCT05611242

• Early use of tirofiban after tenecteplase for acute ischemic stroke

  This test sees if giving the antiplatelet drug tirofiban soon after tenecteplase helps adults with acute ischemic stroke avoid reocclusion and improve recovery.

  Recruiting at 38 sites Phase 3 Second Affiliated Hospital of Guangxi Medical University · Chuzhou, Anhui and 37 other locations · NCT05604638

• Evaluating head acupuncture after thrombectomy for stroke treatment

  This study is testing if adding head acupuncture to standard treatment after a stroke helps patients recover better than just the standard treatment alone.

  Recruiting Xi'an No.3 Hospital · Xi'an, Shaanxi · NCT05561088

• Using a standardized treatment system for acute ischemic stroke in Xi'an

  This study looks at how a quick treatment system for acute ischemic stroke helps patients in Xi'an recover and what happens to them in the following months.

  Recruiting Xi'an No.3 Hospital · Xi'an, Shaanxi · NCT05424978

• Adding TBO-309 to reperfusion treatment for acute ischemic stroke.

  This trial will test whether giving the antiplatelet drug TBO-309 together with clot-dissolving or clot-removal treatment is safe for adults who have just had an acute ischemic stroke.

  Recruiting at 7 sites Phase 2 The Florey Institute of Neuroscience and Mental Health · Camperdown, New South Wales and 6 other locations · NCT05363397

• Identifying biomarkers for early detection of acute stroke

  This study is trying to find specific markers in blood and saliva that can help doctors quickly and accurately diagnose strokes in adults who come to the emergency room with symptoms.

  Recruiting The University of Hong Kong · Hong Kong · NCT05300997

• Early rhythm-control therapy for stroke patients with atrial fibrillation

  This trial tests whether starting rhythm-control treatment early after an acute ischemic stroke in people with atrial fibrillation can reduce recurrent strokes and other heart-related problems, compared with usual care.

  Recruiting Phase 3 Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT05293080

• Registry of acute ischemic stroke patients at Xuanwu Hospital

  This study looks at how well a special fast-track treatment system works for patients with acute ischemic stroke at Xuanwu Hospital in China.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT05208203

• Treatment of acute stroke caused by carotid artery issues using a specialized stent

  This study is testing a special stent treatment for people who have had a stroke caused by problems in their carotid artery to see if it helps them recover better.

  Recruiting John Paul II Hospital, Krakow · Krakow · NCT05195658

• Evaluating the safety and usability of BALT medical devices for various brain and vascular conditions

  This study is testing how safe and effective BALT medical devices are for treating brain and blood vessel conditions like aneurysms and strokes.

  Recruiting at 10 sites Balt Extrusion · Angers and 11 other locations · NCT04927156

• Prolonged sedation with dexmedetomidine after stroke treatment

  This study tests if using a sedative called dexmedetomidine after stroke treatment can help patients recover better compared to a placebo.

  Recruiting Phase 4 Beijing Chao Yang Hospital · Beijing, Beijing Municipality · NCT04916197

• Improving treatment for patients with severe strokes

  This study is trying to find better ways to treat patients with severe strokes by looking at their brain scans and treatment outcomes to see what works best.

  Recruiting at 2 sites Universitätsklinikum Hamburg-Eppendorf · Berlin and 7 other locations · NCT04862507

• Registry for assessing thrombus removal in acute ischemic stroke patients

  This study is testing how well the NeVa stent retriever works for removing blood clots in patients who have had a stroke caused by blocked large blood vessels.

  Recruiting at 3 sites Vesalio · Mendoza and 2 other locations · NCT04562194

• EmboTrap II clot retriever for re-opening blocked brain arteries in acute ischemic stroke

  This registry will see if the EmboTrap II clot retriever can safely and effectively reopen large blocked brain arteries in adults with acute ischemic stroke treated within 12 hours.

  Recruiting Niguarda Hospital · Milan · NCT03601702

• Registry for endovascular treatment of acute ischemic stroke in Germany

  This study is collecting information from patients in Germany who are receiving special procedures for acute ischemic stroke to see how well these treatments work and how safe they are.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT03356392

• Registry for blood and tissue samples from stroke patients

  This study is collecting blood and tissue samples from stroke patients to see if they can find clues that help understand stroke better and lead to new treatments.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT03153683

NIH-funded research (31)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeted nanomedicine to protect the brain after stroke

  A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11504265

• Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy

  A research project is creating better computer models and animal studies to help remove clots more safely and effectively in people who have an acute ischemic stroke.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11464942

• Nanoparticle-delivered tPA to overcome clot resistance in acute ischemic stroke

  A Mayo Clinic team is testing a nanoparticle-delivered tPA approach to help dissolve clots more effectively in people with acute ischemic stroke due to large vessel blockage.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11445896

• Engineered tissue regulatory T cells as a treatment for stroke

  A new off-the-shelf cell therapy using engineered regulatory T cells could help people who have an ischemic stroke recover by reducing inflammation and promoting tissue repair.

  NIH research Gentibio, INC. · Cambridge, United States · NIH-11396531

• Fast penumbral imaging to guide stroke treatment

  Aims to develop quick MRI techniques to identify tissue at risk in acute ischemic stroke and help decide whether to use advanced clot-busting treatment.

  NIH research Emory University · Atlanta, United States · NIH-11393050

• Circadian factors shaping reperfusion success in acute stroke

  This grant looks at how the body’s internal clock might influence how well stroke patients respond to clot-busting or clot-removal treatments.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11389678

• A practical brain-cooling device to protect the brain during acute ischemic stroke

  A new, patient-friendly endovascular cooling system aims to protect brain tissue during emergency stroke treatment to improve recovery.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11371687

• MRI-based brain oxygen use map to guide stroke treatment

  A new MRI-based method to measure how much oxygen the brain is using during an acute stroke, to help doctors decide on the best treatment for patients.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11369600

• Benzodiazepine use after stroke in older adults with dementia

  This project looks at how benzodiazepines are prescribed to people 65 and older who survived a stroke and have Alzheimer's or related dementias, and whether those prescriptions affect health outcomes.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11363589

• Abbreviated heart MRI to quickly find stroke causes

  A short MRI-based test is being developed to quickly and affordably identify the cause of an acute ischemic stroke in patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11310485

• Dynamic brain blood vessel changes after a stroke and how they relate to recovery

  This project looks at how blood vessels in the brain change after an acute ischemic stroke and whether those changes can help predict a patient’s recovery.

  NIH research University of California Riverside · Riverside, United States · NIH-11306002

• Better Brain Oxygen Measurement for Acute Stroke

  This project aims to create an easier MRI method to see how much oxygen your brain uses after a stroke, helping doctors make quicker treatment choices.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11145813

• Reducing Brain Damage in Acute Stroke with a New Blood Substitute

  This project explores a new blood substitute to help protect brain cells and limit damage after an acute ischemic stroke.

  NIH research University of Chicago · Chicago, United States · NIH-11143286

• Understanding the Connection Between Lungs and Brain After Stroke

  This project explores how the lungs and brain communicate after an acute stroke to find new ways to help patients recover.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11143165

• Faster MRI to find salvageable brain tissue after stroke

  This project is developing faster MRI scans that spot at-risk but still-salvageable brain tissue for people with acute ischemic stroke so doctors can make quicker treatment decisions.

  NIH research Emory University · Atlanta, United States · NIH-11137792

• Improving drug delivery to the brain after a stroke using targeted nanomedicine

  This study is exploring a new way to deliver medicine directly to the damaged parts of the brain during a stroke, using tiny carriers that can find and target those areas, which could make treatments more effective for people experiencing an acute ischemic stroke.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11103390

• Changes in blood vessel structure after a stroke

  This study looks at how blood vessels in the brain change after a stroke and how different treatments can help restore blood flow, with the goal of better understanding recovery and improving care for stroke patients.

  NIH research University of California Riverside · Riverside, United States · NIH-11076680

• Investigating how endothelial cell fat metabolism affects outcomes after a stroke

  This study is looking at how fat in brain cells affects recovery after a stroke, and it aims to find out if lowering certain fat molecules can help improve healing and movement for people who have had a stroke.

  NIH research University of Utah · Salt Lake City, United States · NIH-11073799

• Investigating a new treatment for acute ischemic stroke using a specific inhibitor.

  This study is looking at how a medication called GSK2256294 might help protect the brain during a stroke by boosting helpful substances that reduce damage and improve blood flow, and it's for both younger and older patients, including those with diabetes and high blood pressure.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11042219

• Mapping oxygen consumption in the brain for stroke evaluation

  This study is testing a new MRI method to measure how much oxygen your brain is using after a stroke, which can help doctors understand how much of your brain is still healthy and make better treatment choices for you.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10990819

• Using a new blood substitute to reduce brain damage in stroke patients

  This study is looking at a new treatment called Sanguinate® that could help reduce brain damage during a stroke by improving blood flow and oxygen delivery to the affected areas, and it’s designed for people who are having a stroke.

  NIH research University of Chicago · Chicago, United States · NIH-10944298

• New treatment to protect brain cells during a stroke

  This study is testing a new treatment that aims to protect brain cells during a stroke, which could help improve recovery and reduce long-term disability for stroke patients.

  NIH research Celdara Medical, LLC · Lebanon, United States · NIH-10932426

• Targeted nanomedicine to protect the brain after an ischemic stroke

  This project uses tiny, targeted drug carriers to bring anti-inflammatory medicine directly into damaged brain tissue after an ischemic stroke to limit injury.

  NIH research Nanomuse, LLC · Princeton Junction, United States · NIH-10932102

• Understanding how heart conditions contribute to strokes

  This study is looking at how certain heart problems might affect recovery after a stroke, and it's for people who have had an acute ischemic stroke to help improve their care and outcomes.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10897041

• Improving recovery from stroke by targeting blood vessel cell metabolism in older mice.

  This study is looking at a new way to help older people recover better from a stroke by improving the health of the cells that line their blood vessels, which could boost blood flow and oxygen to the brain.

  NIH research University of Utah · Salt Lake City, United States · NIH-10811525

• A new way to protect the brain and improve recovery after an ischemic stroke

  Developing a treatment to protect brain tissue and help people recover better after a sudden ischemic stroke treated with clot removal.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10795767

• Using advanced MRI to improve treatment for acute ischemic stroke patients

  This study is looking at a new way to use special MRI scans to find brain areas that are still healthy enough to treat after a stroke, even if it's been a while since the stroke happened, so that more patients can get the help they need to recover.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10794203

• Monitoring blood flow in the brain during stroke treatment

  This study is testing a new, noninvasive way to check blood flow in the brain during and after treatment for strokes, using a special tool that helps doctors catch any problems early and improve care for patients.

  NIH research University of South Florida · Tampa, United States · NIH-10771295

• Improving treatment for acute ischemic stroke using advanced modeling techniques

  This study is looking at how blood clots form in the brain and why some can be removed easily while others can't, with the goal of helping doctors improve treatments for people who have had a stroke.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-10613506

• New nanomedicine approach for treating acute ischemic stroke

  This study is testing a new way to deliver brain-protecting medications directly to the brain for people who have had a stroke, hoping to help them recover better after treatment.

  NIH research Nanomuse, LLC · Princeton Junction, United States · NIH-10603229

• New methods to protect the brain and improve recovery after a stroke

  This study is looking at new ways to help people recover better after an ischemic stroke by testing a combination of special treatments with current methods, so that patients can have less long-term damage and improve their overall health.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10584833

Related topics

Quick answers

How many Acute Ischemic Stroke clinical trials are recruiting right now?

141, as of November 12, 2026. 4 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 41 countries. The most sites are in China (87 trials), United States (19 trials), Germany (11 trials), Spain (10 trials), France (8 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 27, Phase 2: 18, Phase 2/3: 5, Phase 4: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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