New methods to protect the brain and improve recovery after a stroke
Official title: New approach to sustained neuroprotection and enhanced recovery following acute ischemic stroke
Funded at Ohio State University · NIH-10584833 · Data updated 2026-11-12
This study is looking at new ways to help people recover better after an ischemic stroke by testing a combination of special treatments with current methods, so that patients can have less long-term damage and improve their overall health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 19, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $1,693,719 |
| NIH project number | 1RF1NS127413-01A1 |
| Project ID | NIH-10584833 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an ischemic stroke, particularly those undergoing EVT treatment.
✕Less likely to help
Patients who have not experienced a stroke or those with other types of strokes may not benefit from this research.
What this research studies
This research focuses on improving outcomes for patients who have suffered an ischemic stroke, which is a major health issue affecting many individuals each year. The study aims to explore the use of neuroprotective agents in combination with existing treatments like mechanical endovascular thrombectomy (EVT) to enhance recovery and reduce long-term neurological damage. By following established guidelines for pre-clinical studies, the research seeks to identify effective therapies that can be translated into clinical practice for better patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and quality of life for stroke patients by reducing long-term neurological damage.
How similar studies have gone: Previous research has shown promise in using neuroprotective agents in experimental models, but translating these findings to clinical success has been challenging, making this approach both novel and critical.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Herson, Paco S — Ohio State University
- Study coordinator: Herson, Paco S
Related research
Other NIH-funded projects on the same topics.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
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Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
A research project is creating better computer models and animal studies to help remove clots more safely and effectively in people who have an acute ischemic stroke.
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Nanoparticle-delivered tPA to overcome clot resistance in acute ischemic stroke
A Mayo Clinic team is testing a nanoparticle-delivered tPA approach to help dissolve clots more effectively in people with acute ischemic stroke due to large vessel blockage.
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Engineered tissue regulatory T cells as a treatment for stroke
A new off-the-shelf cell therapy using engineered regulatory T cells could help people who have an ischemic stroke recover by reducing inflammation and promoting tissue repair.
-
Fast penumbral imaging to guide stroke treatment
Aims to develop quick MRI techniques to identify tissue at risk in acute ischemic stroke and help decide whether to use advanced clot-busting treatment.
-
Circadian factors shaping reperfusion success in acute stroke
This grant looks at how the body’s internal clock might influence how well stroke patients respond to clot-busting or clot-removal treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.