Prophylactic Stress Ulcer Drugs and Outcomes After Mechanical Thrombectomy in Acute Ischemic Stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort investigates the relationship between pharmacological stress ulcer prophylaxis and clinical outcomes in adults who underwent mechanical thrombectomy for acute anterior circulation large vessel occlusion. The study notes that stress ulcer bleeding, though relatively uncommon, is associated with worse outcomes, and guidelines do not routinely endorse prophylaxis, making evidence in this setting important. Eligible participants are adults treated within 24 hours of stroke onset, who meet specified guideline-based criteria and have undergone thrombectomy. The analysis aims to identify correlations between prophylaxis use and outcomes such as mortality, functional status, or bleeding events. The study is conducted across multiple centers in China with collaboration among several institutions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years.
2. Within 24 hours of onset. Meet the criteria for diagnosis of acute ischemic stroke in the "China Acute Ischemic Stroke Diagnosis and Treatment Guidelines 2018".
3. Meet the indications for mechanical thrombectomy in the "Chinese Guidelines for Early Endovascular Interventions in Acute Ischemic Stroke 2022".
4. Treated with mechanical thrombectomy.
5. NIHSS score ≥ 6 at onset of illness.
6. Sign an informed notice.

Exclusion Criteria:

Allergy to drug ingredients. Women who are pregnant or breastfeeding. Life expectancy of less than 3 months due to other non-ischemic stroke diseases such as malignancy, severe liver or renal failure.

Have participated in other interventional clinical studies (affecting the outcome of this cohort study).

Participants who were judged by the investigator to be unsuitable for participation in this study.

Where it's running

• Fujian Medical University Union Hospital
  Fuzhou, Fujian, China Recruiting
• Dongguan donghua hospital
  Dongguan, Guangdong, China Recruiting
• Dongguan People's Hospital
  Dongguan, Guangdong, China Recruiting
• Guangdong Provincial Hospital of Traditional Chinese Medicine
  Guangzhou, Guangdong, China Recruiting
• Huadu District People's Hospital of Guangzhou
  Guangzhou, Guangdong, China Recruiting
• Nanfang Hospital of Southern Medical University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Suyue Pan — Department of Neurology, Nanfang Hospital,Southern Medical University
• Study coordinator: Suyue Pan, M.D., Ph.D.
• Email: pansuyue@smu.edu.cn
• Phone: 13556184981

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.