Nanoparticle-delivered tPA to overcome clot resistance in acute ischemic stroke
Official title: Thrombolysis Resistance in Acute Ischemic Stroke
Funded at Mayo Clinic Rochester · NIH-11445896 · Data updated 2026-11-12
A Mayo Clinic team is testing a nanoparticle-delivered tPA approach to help dissolve clots more effectively in people with acute ischemic stroke due to large vessel blockage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 15, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $593,663 |
| NIH project number | 1R01HL184127-01A1 |
| Project ID | NIH-11445896 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with acute ischemic stroke due to large vessel occlusion, whose clots are eligible for tPA-based approaches or nanoparticle-adjunct therapies.
✕Less likely to help
Patients whose clots are not accessible to tPA-based strategies or who have contraindications to tPA.
What this research studies
This project looks at why tissue plasminogen activator (tPA) often fails to dissolve clots in large vessel stroke and explores how the clot’s acidic environment and microbial signals contribute to resistance. Researchers will use patient clot samples and advanced analyses to map metabolic changes and hypoxia, then test a targeted, fibrin-specific nanoparticle delivery of tPA. The goal is to improve recanalization rates and outcomes when mechanical thrombectomy is not enough or not available. The work combines laboratory studies with analyses on human clots to identify actionable strategies for rescue therapy in AIS. If successful, this approach could lead to a new treatment option that works better in real-world stroke care.
Why it matters
Potential benefit: If successful, patients could have higher chances of clot dissolution and improved recovery after a stroke.
How similar studies have gone: Previous work shows metabolic and hypoxic features in AIS clots; this project adds a targeted nanoparticle delivery to overcome these barriers.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Kadirvel, Ramanathan — Mayo Clinic Rochester
- Study coordinator: Kadirvel, Ramanathan
Related research
Other NIH-funded projects on the same topics.
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Engineered tissue regulatory T cells as a treatment for stroke
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Circadian factors shaping reperfusion success in acute stroke
This grant looks at how the body’s internal clock might influence how well stroke patients respond to clot-busting or clot-removal treatments.
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A practical brain-cooling device to protect the brain during acute ischemic stroke
A new, patient-friendly endovascular cooling system aims to protect brain tissue during emergency stroke treatment to improve recovery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.