BDNF Levels and Cardioembolic Stroke in Ischemic Stroke Patients
Official title: Association Between Circulating BDNF Levels and Cardioembolic Strokes in Patients Treated for Ischemic Stroke
Run by Centre Hospitalier Universitaire Dijon · NCT07624396 · Data updated 2026-11-12
This study tests whether blood levels of brain-derived neurotrophic factor (BDNF) relate to cardioembolic stroke risk in people who have had an acute ischemic stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 1 site (Dijon) |
| Status | Recruiting |
| Started | September 23, 2026 |
| Main results expected | September 2031 |
| Study ends | September 2031 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT07624396 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with acute ischemic stroke confirmed by imaging who had a combined cardiac and brain CT within 24 hours of admission and provided informed consent at Dijon Bourgogne University Hospital.
✕Probably not a fit
Patients in whom BDNF levels do not correlate with cardioembolic risk or those unable to enroll due to consent or eligibility constraints may not benefit from biomarker insights.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study examines the relationship between circulating BDNF levels and cardioembolic stroke among adults with acute ischemic stroke. Blood samples are used to measure BDNF, and participants are identified from a single center in Dijon, France, within 24 hours of stroke admission after a combined cardiac and brain CT scan. The goal is to better understand how BDNF may reflect atrial cardiomyopathy and the risk of embolic events. No experimental treatment is administered; the study uses biomarker data to explore potential associations in an observational framework.
Why it matters
Potential benefit: If a link is found, BDNF could serve as a biomarker to help identify patients at risk of cardioembolic complications after ischemic stroke.
How similar studies have gone: Previous research has explored neurotrophic factors in cerebrovascular disease, but the specific association between circulating BDNF and cardioembolic stroke remains exploratory and not yet established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals who provided informed consent * Diagnosis of acute ischemic stroke confirmed by brain imaging (CT or MRI) * Patient admitted to the USINV of the Department of General, Vascular, and Degenerative Neurology at the Dijon Bourgogne University Hospital during the inclusion period * Underwent a combined cardiac and brain CT scan within 24 hours of admission for stroke Exclusion Criteria: * A person subject to a legal protective measure (guardianship, conservatorship) * A person subject to a judicial safeguard measure * A pregnant woman, a woman who has recently given birth, or a breastfeeding woman * An adult who is legally incapacitated or unable to give consent, * A minor
Where it's running
-
Chu Dijon Bourgogne
Dijon, France Recruiting
Study contacts
- Study coordinator: Charles GUENANCIA, Pr
- Email: charles.guenancia@chu-dijon.fr
- Phone: 03.80.29.56.23
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.