Clinical trial Recruiting at 1 site Interventional Ages 40 to 80

Comparing regional and general anesthesia for carotid surgery in stroke patients

Official title: The Study is Planned to Evaluate the Effectiveness and Safety of Two Types of Anesthesia (Regional and General) for Carotid Endarterectomy in 100 Patients With Acute Stage of Stroke: 50 Patients Will be Operated Under Regional Anesthesia and the Remaining 50 Patients Under General Anesthesia.

Run by Pirogov Russian National Research Medical University · NCT06175715 · Data updated 2026-11-12

This study is testing whether regional anesthesia is safer and more effective than general anesthesia for stroke patients undergoing carotid surgery.

More Acute Ischemic Stroke trials

Quick facts

Study typeInterventional
Ages40 Years to 80 Years
SexAll
Enrollment100 (estimated)
SponsorPirogov Russian National Research Medical University
Academic / other
Locations1 site (Moscow)
StatusRecruiting
StartedJuly 1, 2024
Main results expectedDecember 31, 2026
Study endsDecember 31, 2028
Registry record updatedMarch 27, 2026
Trial IDNCT06175715 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients with acute ischemic stroke in the middle cerebral artery territory and significant internal carotid artery stenosis.

Probably not a fit

Patients with contraindications for either type of anesthesia or those outside the specified time frame post-stroke may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness and safety of regional versus general anesthesia during carotid endarterectomy in patients experiencing acute ischemic stroke. A total of 100 patients will be enrolled, with 50 receiving regional anesthesia and 50 receiving general anesthesia. The study aims to assess perioperative complications, including the occurrence of ipsilateral ischemic strokes and other stroke types within 30 days post-surgery. The inclusion criteria focus on patients with specific neurological deficits and ischemic conditions.

Why it matters

Potential benefit: If successful, this study could help determine the safest and most effective anesthesia method for stroke patients undergoing carotid endarterectomy.

How similar studies have gone: While there have been studies comparing anesthesia methods in various surgical contexts, this specific approach in acute ischemic stroke patients is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 1\. Ischemic stroke in the middle cerebral artery territory 2. Ipsilateral stenosis of the internal carotid artery more than 50% 3. Neurological deficit at the time of surgical treatment: the modified Rankin scale (mRs) score of 0-4 and the US National Institutes of Health (NIHSS) stroke scale score no more than 12 4. The size of the ischemia focus: no more than 1/3 in the territory of the middle cerebral artery brain supply 5. Terms of operation: from 1 to 28 days from the moment of ischemic stroke

Exclusion Criteria:

\-

Where it's running

  • Pryamikov Aleksandr
    Moscow, Russia
    Recruiting

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.