Improving treatment for patients with severe strokes
Improving Low Alberta Stroke Program Early ct Score Stroke Thrombectomy
Universitätsklinikum Hamburg-Eppendorf · NCT04862507
This study is trying to find better ways to treat patients with severe strokes by looking at their brain scans and treatment outcomes to see what works best.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitätsklinikum Hamburg-Eppendorf (other) |
| Locations | 8 sites (Berlin and 7 other locations) |
| Trial ID | NCT04862507 on ClinicalTrials.gov |
What this trial studies
This observational study aims to enhance the treatment of patients with acute ischemic stroke who have low ASPECTS scores, indicating extensive brain infarction. Conducted across multiple German stroke centers, it will collect data on patients receiving endovascular stroke treatment, including clinical and procedural information, as well as follow-up data for up to 90 days post-stroke. The study focuses on validating advanced imaging biomarkers to improve treatment selection and predict outcomes for these patients, particularly those with significant baseline infarction. By analyzing factors such as lesion water uptake and collateral circulation, the study seeks to refine patient management and treatment strategies.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old with a clinical diagnosis of acute ischemic stroke and an ASPECTS score of 0-5.
Not a fit: Patients with conditions other than acute ischemic stroke or those with higher ASPECTS scores may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment outcomes for patients with severe strokes by better predicting who will benefit from reperfusion therapy.
How similar studies have performed: Other studies have shown promise in using advanced imaging techniques to guide treatment decisions in stroke patients, suggesting a potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of acute ischemic stroke * ASPECTS of 0-5 * Confirmed diagnosis of persistent occlusion of terminal carotid artery, middle cerebral artery (M1 or M2), or basilar artery consistent with symptoms * Age \>18 years * Ethic approval in process Exclusion Criteria: none
Where this trial is running
Berlin and 7 other locations
- Charite University Berlin — Berlin, Germany (ENROLLING_BY_INVITATION)
- Hospital Bremen-Mitte — Bremen, Germany (ENROLLING_BY_INVITATION)
- University Medical Center Hamburg-Eppendorf — Hamburg, Germany (RECRUITING)
- Westpfalzklinikum — Kaiserslautern, Germany (ENROLLING_BY_INVITATION)
- University Hospital Marburg — Marburg, Germany (RECRUITING)
- University Münster — Münster, Germany (ENROLLING_BY_INVITATION)
- University Rostock — Rostock, Germany (ENROLLING_BY_INVITATION)
- University Basel — Basel, Switzerland (ENROLLING_BY_INVITATION)
Study contacts
- Study coordinator: Gabriel Broocks, MD
- Email: g.broocks@uke.de
- Phone: +4915222817182
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Ischemic Stroke