Improving treatment for patients with severe strokes
Official title: Improving Low Alberta Stroke Program Early ct Score Stroke Thrombectomy
Run by Universitätsklinikum Hamburg-Eppendorf · NCT04862507 · Data updated 2026-11-12
This study is trying to find better ways to treat patients with severe strokes by looking at their brain scans and treatment outcomes to see what works best.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Universitätsklinikum Hamburg-Eppendorf Academic / other |
| Locations | 8 sites (Berlin and 7 other locations) |
| Status | Recruiting |
| Started | May 1, 2023 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2028 |
| Registry record updated | May 24, 2023 |
| Trial ID | NCT04862507 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 years old with a clinical diagnosis of acute ischemic stroke and an ASPECTS score of 0-5.
✕Probably not a fit
Patients with conditions other than acute ischemic stroke or those with higher ASPECTS scores may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to enhance the treatment of patients with acute ischemic stroke who have low ASPECTS scores, indicating extensive brain infarction. Conducted across multiple German stroke centers, it will collect data on patients receiving endovascular stroke treatment, including clinical and procedural information, as well as follow-up data for up to 90 days post-stroke. The study focuses on validating advanced imaging biomarkers to improve treatment selection and predict outcomes for these patients, particularly those with significant baseline infarction. By analyzing factors such as lesion water uptake and collateral circulation, the study seeks to refine patient management and treatment strategies.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment outcomes for patients with severe strokes by better predicting who will benefit from reperfusion therapy.
How similar studies have gone: Other studies have shown promise in using advanced imaging techniques to guide treatment decisions in stroke patients, suggesting a potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of acute ischemic stroke * ASPECTS of 0-5 * Confirmed diagnosis of persistent occlusion of terminal carotid artery, middle cerebral artery (M1 or M2), or basilar artery consistent with symptoms * Age \>18 years * Ethic approval in process Exclusion Criteria: none
Where it's running
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University Medical Center Hamburg-Eppendorf
Hamburg, Germany Recruiting -
University Hospital Marburg
Marburg, Germany Recruiting -
Charite University Berlin
Berlin, Germany Enrolling by invitation -
Hospital Bremen-Mitte
Bremen, Germany Enrolling by invitation -
Westpfalzklinikum
Kaiserslautern, Germany Enrolling by invitation -
University Münster
Münster, Germany Enrolling by invitation
Show 2 more locations
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University Rostock
Rostock, Germany Enrolling by invitation -
University Basel
Basel, Switzerland Enrolling by invitation
Study contacts
- Study coordinator: Gabriel Broocks, MD
- Email: g.broocks@uke.de
- Phone: +4915222817182
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Short-Term outside-in nerve stimulation for acute ischemic stroke
This trial tests whether a 5-day external trigeminal nerve stimulation given after stroke can help more patients recover better than a sham treatment.
-
Sevoflurane vs. Propofol for anesthesia in stroke patients undergoing clot-removal
This study tests whether sevoflurane or propofol used for anesthesia during endovascular treatment of an acute ischemic stroke affects the final brain damage and recovery.
-
Safety of adding NRICM301 to standard care for adults with acute ischemic stroke
This study tests whether adding NRICM301, a traditional Chinese medicine formula, to usual care is safe for adults with acute ischemic stroke.
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Intracranial Recanalization with LT3001 in Acute Ischemic Stroke
This phase II study tests whether LT3001 given to adults with acute ischemic stroke can help reopen blocked brain arteries.
-
Mobilisation After Endovascular Stroke Treatment
This study checks whether moving around 12 hours after endovascular stroke treatment is as safe as moving around 24 hours for people with an acute ischemic stroke.
-
Endovascular therapy plus standard care vs standard care alone for distal and medium vessel strokes
In people with acute ischemic stroke due to distal or medium vessel blockages, this study tests whether adding endovascular treatment to the usual medical care helps improve outcomes compared with medical care alone.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.