Understanding the Connection Between Lungs and Brain After Stroke
Official title: Lung-Brain Coupling and the Immune Response to Acute Ischemic Stroke
Funded at State University of New York at Buffalo · NIH-11143165 · Data updated 2026-11-12
This project explores how the lungs and brain communicate after an acute stroke to find new ways to help patients recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | May 1, 2015 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $555,607 |
| NIH project number | 5R01NS092455-11 |
| Project ID | NIH-11143165 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have experienced an acute ischemic stroke might eventually benefit from the findings of this research.
✕Less likely to help
Patients with other types of brain injuries or chronic conditions not related to acute ischemic stroke may not directly benefit from this specific research.
What this research studies
After a stroke, the brain and immune system interact in ways that can worsen damage. We've found a new connection between the lungs and brain that influences the body's immune response and can lead to more brain damage. This work aims to understand how stroke affects the lungs and how these lung changes impact the brain. We are looking into whether protecting the lungs after a stroke could reduce inflammation and improve recovery for patients.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target lung health after a stroke, potentially reducing inflammation and improving recovery for patients.
How similar studies have gone: This research explores a novel mechanism of lung-brain coupling after stroke, indicating a new and untested approach for targeted therapies.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Halterman, Marc W — State University of New York at Buffalo
- Study coordinator: Halterman, Marc W
Related research
Other NIH-funded projects on the same topics.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
A research project is creating better computer models and animal studies to help remove clots more safely and effectively in people who have an acute ischemic stroke.
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Nanoparticle-delivered tPA to overcome clot resistance in acute ischemic stroke
A Mayo Clinic team is testing a nanoparticle-delivered tPA approach to help dissolve clots more effectively in people with acute ischemic stroke due to large vessel blockage.
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Engineered tissue regulatory T cells as a treatment for stroke
A new off-the-shelf cell therapy using engineered regulatory T cells could help people who have an ischemic stroke recover by reducing inflammation and promoting tissue repair.
-
Fast penumbral imaging to guide stroke treatment
Aims to develop quick MRI techniques to identify tissue at risk in acute ischemic stroke and help decide whether to use advanced clot-busting treatment.
-
Circadian factors shaping reperfusion success in acute stroke
This grant looks at how the body’s internal clock might influence how well stroke patients respond to clot-busting or clot-removal treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.