Using advanced MRI to improve treatment for acute ischemic stroke patients
Official title: Ultrafast Quantitative pH MRI for Acute Ischemic Stroke Patients
Funded at Johns Hopkins University · NIH-10794203 · Data updated 2026-11-12
This study is looking at a new way to use special MRI scans to find brain areas that are still healthy enough to treat after a stroke, even if it's been a while since the stroke happened, so that more patients can get the help they need to recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 15, 2020 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $373,268 |
| NIH project number | 5R01NS112242-05 |
| Project ID | NIH-10794203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients experiencing acute ischemic stroke, particularly those who present beyond the typical treatment time frames.
✕Less likely to help
Patients who have experienced hemorrhagic strokes or those with conditions that contraindicate MRI may not benefit from this research.
What this research studies
This research focuses on enhancing the treatment of acute ischemic stroke by utilizing ultrafast quantitative pH MRI to identify brain tissue that is at risk but still viable for treatment. The approach aims to improve the accuracy of identifying salvageable brain tissue, which is crucial for effective reperfusion therapy. By optimizing imaging protocols, the study seeks to provide better guidance for treatment decisions, especially for patients who present beyond the standard treatment time windows. This could potentially expand the eligibility for life-saving therapies in stroke patients.
Why it matters
Potential benefit: If successful, this research could significantly increase the number of stroke patients who can receive effective treatment, potentially reducing morbidity and mortality associated with strokes.
How similar studies have gone: Previous studies have shown promise in using advanced MRI techniques for stroke assessment, but this specific approach is novel and aims to refine existing methods.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Heo, Hye Young — Johns Hopkins University
- Study coordinator: Heo, Hye Young
Related research
Other NIH-funded projects on the same topics.
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Abbreviated heart MRI to quickly find stroke causes
A short MRI-based test is being developed to quickly and affordably identify the cause of an acute ischemic stroke in patients.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
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Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
A research project is creating better computer models and animal studies to help remove clots more safely and effectively in people who have an acute ischemic stroke.
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Nanoparticle-delivered tPA to overcome clot resistance in acute ischemic stroke
A Mayo Clinic team is testing a nanoparticle-delivered tPA approach to help dissolve clots more effectively in people with acute ischemic stroke due to large vessel blockage.
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Engineered tissue regulatory T cells as a treatment for stroke
A new off-the-shelf cell therapy using engineered regulatory T cells could help people who have an ischemic stroke recover by reducing inflammation and promoting tissue repair.
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Fast penumbral imaging to guide stroke treatment
Aims to develop quick MRI techniques to identify tissue at risk in acute ischemic stroke and help decide whether to use advanced clot-busting treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.