MRI-based brain oxygen use map to guide stroke treatment
Official title: Quantitative Cerebral Oxygen Metabolic Imaging of Acute Ischemic Stroke
Funded at Weill Medical Coll of Cornell Univ · NIH-11369600 · Data updated 2026-11-12
A new MRI-based method to measure how much oxygen the brain is using during an acute stroke, to help doctors decide on the best treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $642,803 |
| NIH project number | 5R01NS135205-03 |
| Project ID | NIH-11369600 on NIH RePORTER |
Who could benefit from this research
✓Could help
People experiencing acute ischemic stroke who are undergoing brain imaging as part of their evaluation.
✕Less likely to help
Patients not eligible for MRI-based imaging or those without acute stroke features may not benefit.
What this research studies
This project aims to create an accessible MRI technique to map the brain's cerebral metabolic rate of oxygen (CMRO2) in people with acute ischemic stroke. By combining MRI measurements of blood flow with a novel MRI-based oxygen extraction assessment, researchers hope to predict which brain tissue is likely to recover versus deteriorate. They will validate the MRI method against the current gold standard PET measurements and compare how well MRI CMRO2 predicts tissue fate compared with traditional imaging. The work is designed to translate into clinical practice so clinicians can make more informed, timely therapeutic decisions for stroke patients.
Why it matters
Potential benefit: If successful, patients with acute stroke could receive more accurate assessments of tissue viability, potentially guiding treatment choices and improving outcomes.
How similar studies have gone: Prior research shows MRI-based biomarkers can reflect brain metabolism, but direct MRI-based CMRO2 validation against PET is ongoing and promising.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Wang, Yi — Weill Medical Coll of Cornell Univ
- Study coordinator: Wang, Yi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.