Evaluating treatment options for stroke patients presenting after 24 hours
Triage of Patients Presenting Beyond 24 Hours From Last Known Well With Acute Ischemic Stroke Due to Large Vessel Occlusions (TRACK-LVO Late): a TRACK-LVO Registry-linked Cohort
This study is trying to see if a special procedure or the best medical care can help stroke patients who arrive at the hospital more than 24 hours after their symptoms started.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Sex | All |
| Sponsor | Tianjin Huanhu Hospital Academic / other |
| Locations | 1 site (Tianjin, Tianjin Municipality) |
| Trial ID | NCT06200753 on ClinicalTrials.gov |
What this trial studies
This observational study aims to create a registry-linked cohort of patients with acute ischemic stroke caused by large vessel occlusions who present to participating centers more than 24 hours after their last known well time. The study will assess the outcomes of patients treated with endovascular therapy or the best available medical management. By focusing on patients with confirmed large vessel occlusions, the study seeks to fill the knowledge gap regarding the efficacy of endovascular therapy beyond the standard treatment window. Comprehensive patient data will be collected to analyze treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates are patients who present with acute ischemic stroke due to large vessel occlusions more than 24 hours after their last known well time.
Not a fit: Patients with any form of cerebral hemorrhage at admission will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the effectiveness of endovascular therapy for stroke patients presenting late, potentially improving treatment protocols.
How similar studies have performed: While there is substantial evidence supporting endovascular therapy within 24 hours, the outcomes for late presentations remain uncertain, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient admitted from Jan. 1st 2018 to Jan. 1st 2028; * Presenting beyond 24 hours from last known well; * Ischemic stroke confirmed by head CT or MRI; * Large vessel occlusion confirmed by head CTA or MRA: intracranial internal carotid artery (ICA), middle cerebral artery (MCA M1/M2), anterior cerebral artery (ACA A1/A2), basilar artery (BA), vertebral artery (VA), and posterior cerebral artery (PCA P1/P2); * Patients receiving either endovascular therapy or best medical treatment. Exclusion Criteria: • Presence of any forms of cerebral hemorrhage on CT/MR at admission.
Where this trial is running
Tianjin, Tianjin Municipality
- Tianjin Huanhu Hospital — Tianjin, Tianjin Municipality, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.