Assessing cognitive impairment in young adults after ischemic stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on young adults aged 18-45 who have experienced an ischemic stroke, a condition affecting a significant number of individuals in France. It aims to evaluate the prevalence and evolution of cognitive impairment in these patients over time through comprehensive neuropsychological assessments and functional evaluations. By conducting repeated assessments, the study seeks to provide valuable longitudinal data on neurocognitive trajectories in this demographic, which is currently lacking in the literature.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: 18 to 45 years.
* Pathology: ischemic stroke diagnosed with brain MRI as per standard clinical practice, with or without occlusion of proximal artery, anterior or posterior circulation.
* Ability to understand and complete study tests and questionnaires: fluent French speaker and reader.
* All patients must be affiliated to a social security scheme.
* Signature of informed consent form.

Exclusion Criteria:

* Pre-existing cognitive impairment (defined as CQI \<78 or clinical dementia).
* Severe functional dependence prior to stroke (defined as Modified Rankin Scale MRS = score 5).
* Any neurological or psychiatric comorbidity.
* Sensory disorders: visual impairment, blindness, deafness.
* Severe acquired phasic disorders: on the expressive oral side, in the presence of an inability to express oneself, which interferes with the collection of responses to neuropsychological tests; and on the receptive oral side, in the presence of an inability to understand the instructions of neuropsychological tests. Phasic functioning is systematically assessed during hospitalization by means of the NIHSS (score ≤ 2 on the "Language" sub-test), and will be rechecked clinically and psychometrically during neuropsychological assessments using the Language Screening Test (LAST) for both expression and oral comprehension. - Severe motor disorders: inability to mobilize the dominant upper limb for written neuropsychological tests.
* Contraindication to MRI.
* Pregnant women.
* HIV-positive patients: interaction of infectious pathology on cognitive functioning. Declarative, no HIV tests will be performed.
* Withdrawal of informed consent.
* Consumption of alcohol and/or narcotics on the day of neuropsychological assessments.

Where it's running

• Nice University Hospital
  Nice, France Recruiting
• cannes Hospital
  Cannes, France Not yet recruiting

Study contacts

• Study coordinator: Marina PASSALBONI
• Email: passalboni.m@chu-nice.fr
• Phone: 04 92 03 27 90

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Short-Term outside-in nerve stimulation for acute ischemic stroke

  This trial tests whether a 5-day external trigeminal nerve stimulation given after stroke can help more patients recover better than a sham treatment.

  Recruiting Xidian University · Xi'an · NCT07911605

• Sevoflurane vs. Propofol for anesthesia in stroke patients undergoing clot-removal

  This study tests whether sevoflurane or propofol used for anesthesia during endovascular treatment of an acute ischemic stroke affects the final brain damage and recovery.

  Recruiting Phase 3 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona · NCT07902791

• Safety of adding NRICM301 to standard care for adults with acute ischemic stroke

  This study tests whether adding NRICM301, a traditional Chinese medicine formula, to usual care is safe for adults with acute ischemic stroke.

  Recruiting En Chu Kong Hospital · New Taipei City · NCT07900503

• Intracranial Recanalization with LT3001 in Acute Ischemic Stroke

  This phase II study tests whether LT3001 given to adults with acute ischemic stroke can help reopen blocked brain arteries.

  Recruiting Phase 2 Lumosa Therapeutics Co., Ltd. · Taichung · NCT07890298

• Mobilisation After Endovascular Stroke Treatment

  This study checks whether moving around 12 hours after endovascular stroke treatment is as safe as moving around 24 hours for people with an acute ischemic stroke.

  Recruiting at 2 sites Karolinska Institutet · Tampere and 1 other locations · NCT07860333

• Endovascular therapy plus standard care vs standard care alone for distal and medium vessel strokes

  In people with acute ischemic stroke due to distal or medium vessel blockages, this study tests whether adding endovascular treatment to the usual medical care helps improve outcomes compared with medical care alone.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Barcelona · NCT07843797

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.