Registry for Endovascular Treatment of Acute Ischemic Stroke
Official title: Acute Ischemic Stroke EndoVascular Therapy: a Multicenter REGISTRY Study (OCIN-AIS-EVT REGISTRY)
Run by Changhai Hospital · NCT05864638 · Data updated 2026-11-12
This study is trying to see how safe and effective a specific treatment for stroke is in helping patients recover after a blocked blood vessel.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 10000 (estimated) |
| Sponsor | Changhai Hospital Academic / other |
| Locations | 1 site (Shanghai) |
| Status | Recruiting |
| Started | May 10, 2023 |
| Main results expected | August 30, 2028 |
| Study ends | August 31, 2028 |
| Registry record updated | January 27, 2025 |
| Trial ID | NCT05864638 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals experiencing acute ischemic stroke due to vessel occlusion in either the anterior or posterior circulation.
✕Probably not a fit
Patients who do not have acute ischemic stroke or those who are not eligible for intravascular therapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The OCIN-AIS-EVT REGISTRY is a prospective, multicenter observational trial designed to evaluate the safety and functional outcomes of endovascular treatment for acute ischemic stroke caused by vessel occlusion. This study will assess patients undergoing intravascular therapy and will measure outcomes using the modified Rankin scale at 90 days post-treatment. By collecting data from multiple centers, the registry aims to reflect routine clinical practice and provide insights into the effectiveness of these interventions.
Why it matters
Potential benefit: If successful, this study could improve treatment protocols and outcomes for patients suffering from acute ischemic stroke.
How similar studies have gone: Other studies have shown promising results with endovascular treatments for acute ischemic stroke, indicating a potential for success in this registry approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Acute ischemic stroke caused by anterior or posterior circulation vessel occlusion confirmed by computed tomography angiography (CTA) or magnetic resonance angiography (MRA) or digital subtraction angiography (DSA) 2. Undergo intravascular therapy (i.e. access to a cath lab and an arterial puncture) 3. The patient or his/her legal representative agreed to participate in the study and has signed the informed consent. Exclusion Criteria: 1\) No exclusion criteria
Where it's running
-
Jianimin Liu
Shanghai, China Recruiting
Study contacts
- Principal investigator: Jianimin Liu, M.D. — Changhai Hospital
- Study coordinator: Pengfei Yang, M.D.
- Email: 15921196312@163.com
- Phone: 86-21-31161784
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Sivelestat added to endovascular clot retrieval for acute anterior circulation stroke
This study tests whether giving sivelestat sodium alongside mechanical thrombectomy helps improve outcomes for adults with acute ischemic stroke due to large vessel occlusion.
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Sevoflurane vs. Propofol for anesthesia in stroke patients undergoing clot-removal
This study tests whether sevoflurane or propofol used for anesthesia during endovascular treatment of an acute ischemic stroke affects the final brain damage and recovery.
-
Tenecteplase or Reteplase Bridging Before Thrombectomy in Acute Ischemic Stroke
This trial tests whether giving tenecteplase or reteplase before mechanical thrombectomy helps people with acute ischemic stroke due to large vessel occlusion, compared with doing thrombectomy alone.
-
Intra-arterial Alteplase after successful reperfusion following mechanical thrombectomy
This trial tests whether giving a small amount of alteplase directly into the artery after a successful thrombectomy helps adults with acute ischemic stroke recover better.
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Injecting methylprednisolone into the artery right after clot removal for large-vessel stroke
This trial will test whether giving methylprednisolone into the artery immediately after successful clot removal, followed by three days of IV methylprednisolone, helps adults with anterior large-vessel occlusion strokes recover better.
-
Non-invasive vagus nerve stimulation to lower inflammation and brain injury markers after acute ischemic stroke
This test tries whether adding non-invasive vagus nerve stimulation to usual care lowers inflammation and blood markers of brain injury in adults with acute ischemic stroke from a large vessel occlusion.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.