Using a new blood substitute to reduce brain damage in stroke patients
Official title: Mitigation of Cerebral Infarct Growth in Acute Ischemic Stroke Using a Novel Blood Substitute
Funded at University of Chicago · NIH-10944298 · Data updated 2026-11-12
This study is looking at a new treatment called Sanguinate® that could help reduce brain damage during a stroke by improving blood flow and oxygen delivery to the affected areas, and it’s designed for people who are having a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $611,570 |
| NIH project number | 1R01NS138410-01 |
| Project ID | NIH-10944298 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing acute ischemic strokes, particularly those with varying degrees of collateral blood circulation.
✕Less likely to help
Patients who have experienced hemorrhagic strokes or those with contraindications to the use of blood substitutes may not benefit from this research.
What this research studies
This research investigates the use of a novel biopharmaceutical agent called Sanguinate® to mitigate the growth of brain damage during acute ischemic strokes. The study focuses on how this blood substitute can enhance blood flow and oxygen delivery to brain tissues that are deprived of oxygen, which is critical in the early stages of a stroke. By improving collateral blood circulation and delivering oxygen directly to affected areas, the research aims to reduce the size of brain infarcts and minimize injury during treatment. Patients experiencing strokes may benefit from this innovative approach that targets the underlying mechanisms of brain injury.
Why it matters
Potential benefit: If successful, this research could significantly reduce brain damage and improve recovery outcomes for stroke patients.
How similar studies have gone: Previous research has shown promise in using blood substitutes for improving oxygen delivery in ischemic conditions, suggesting potential for success in this novel application.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Carroll, Timothy J — University of Chicago
- Study coordinator: Carroll, Timothy J
Related research
Other NIH-funded projects on the same topics.
-
Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
A research project is creating better computer models and animal studies to help remove clots more safely and effectively in people who have an acute ischemic stroke.
-
Nanoparticle-delivered tPA to overcome clot resistance in acute ischemic stroke
A Mayo Clinic team is testing a nanoparticle-delivered tPA approach to help dissolve clots more effectively in people with acute ischemic stroke due to large vessel blockage.
-
Engineered tissue regulatory T cells as a treatment for stroke
A new off-the-shelf cell therapy using engineered regulatory T cells could help people who have an ischemic stroke recover by reducing inflammation and promoting tissue repair.
-
Fast penumbral imaging to guide stroke treatment
Aims to develop quick MRI techniques to identify tissue at risk in acute ischemic stroke and help decide whether to use advanced clot-busting treatment.
-
Circadian factors shaping reperfusion success in acute stroke
This grant looks at how the body’s internal clock might influence how well stroke patients respond to clot-busting or clot-removal treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.