Sevoflurane vs. Propofol for anesthesia in stroke patients undergoing clot-removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The SAVE trial is a phase 3 randomized study comparing two general anesthesia drugs, sevoflurane and propofol, in adults with acute ischemic stroke due to large vessel occlusion who are treated with endovascular therapy. Participants are randomly assigned to receive one of the two anesthetics during the procedure, and the final infarct volume is measured by MRI about 72 hours after treatment. Clinical outcomes are followed for up to 90 days. The trial aims to determine if the choice of anesthetic influences brain tissue damage and patient recovery, across seven hospitals in Spain, enrolling about 314 participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age over 18 years.
* Acute ischemic stroke within 24 hours from last time seen well, requiring emergency endovascular treatment, with or without prior thrombolysis.
* Intracranial anterior circulation occlusion, including occlusions of the M1 or M2 segments of the middle cerebral artery and/or the terminal internal carotid artery (TICA). Tandem lesions involving extracranial segments of the internal carotid artery are also eligible.
* Alberta Stroke Program Early CT Score (ASPECTS) ≥6 on baseline computed tomography (CT).
* Pre-stroke modified Rankin Scale (mRS) score of 0-3.
* Indication for general anesthesia at the start of the procedure (within 30 minutes from femoral puncture) due to patient confusion or lack of cooperation, technical difficulties, or the treating team's preference.
* Ability to provide informed consent by the patient or by a family member/legal representative.

Exclusion Criteria:

* Hemorrhagic lesions on baseline CT.
* Anterior cerebral artery (ACA) occlusion.
* Posterior circulation occlusion, including vertebral, basilar, or posterior cerebral arteries (PCA).
* Hemodynamic instability.
* Acute respiratory failure requiring orotracheal intubation.
* General anesthesia required because of complications during endovascular treatment.
* Known hypersensitivity to propofol, sevoflurane, or any of their excipients.
* Personal or family history of malignant hyperthermia, or suspected susceptibility to malignant hyperthermia.
* History of a previous serious adverse reaction to halogenated anesthetics, including hepatotoxicity associated with their use.

Where it's running

• Hospital de la Santa Creu i Sant Pau
  Barcelona, Spain Recruiting

Study contacts

• Study coordinator: Pol Camps-Renom
• Email: pcamps@santpau.cat
• Phone: +34935537143

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.