A new way to protect the brain and improve recovery after an ischemic stroke
New approach to sustained neuroprotection and enhanced recovery following acute ischemic stroke
Developing a treatment to protect brain tissue and help people recover better after a sudden ischemic stroke treated with clot removal.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10795767 on NIH RePORTER |
What this research studies
This project tests a novel neuroprotective drug in models of large-vessel ischemic stroke that mimic clot removal (endovascular thrombectomy). The researchers follow updated STAIR guidelines and use rigorous preclinical methods to measure how the drug changes brain injury and recovery when given with reperfusion. They will study timing, safety signals, and biological effects in animal and laboratory models to decide whether the approach justifies human trials. Findings will guide the design of future clinical studies combining this neuroprotectant with current stroke therapies.
Who could benefit from this research
Good fit: Ultimately, ideal candidates would be adults who suffer an acute large-vessel ischemic stroke and receive endovascular thrombectomy.
Not a fit: People with hemorrhagic (bleeding) strokes, chronic stable stroke deficits, or strokes not treated with thrombectomy are unlikely to benefit from this specific approach.
Why it matters
Potential benefit: If successful, the approach could reduce long-term brain damage and improve functional recovery after large ischemic strokes when used alongside clot-removal procedures.
How similar studies have performed: Many compounds have reduced stroke injury in animal models but largely failed in human trials, so this preclinical work applies stricter STAIR-based methods to improve chances of translation.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Herson, Paco S — Ohio State University
- Study coordinator: Herson, Paco S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.