Intravenous Tenecteplase in Very Old Adults with Acute Ischemic Stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, prospective, observational registry that collects real-world data on the safety and effectiveness of intravenous tenecteplase in AIS patients aged 80 years or older treated within 4.5 hours. The primary goal is to see how many patients achieve an excellent outcome (modified Rankin Scale 0-1) at 90 days. Enrollment targets at least 392 participants, with no fewer than 196 receiving tenecteplase, alongside standard medical care. The study design does not randomize treatment and reflects real-world clinical practice across participating centers. Outcomes will inform on feasibility, safety, and potential benefit in this very elderly population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \> 80 years;
2. Clinically diagnosed with acute ischemic stroke and arrived at the hospital within 4.5 hours of symptom onset;
3. Informed consent signed by the patient or legally authorized representative.

Exclusion Criteria:

1. Any contraindication to intravenous thrombolysis (excluding age);
2. Previous treatment with other thrombolytic agents such as alteplase, urokinase, plasminogen activator, or reteplase;
3. Current participation in other interventional studies;
4. The investigator deems the patient unsuitable for this study or the study might pose significant risk to the patient (e.g., due to psychiatric disorders, cognitive or emotional impairments that prevent understanding or adherence to study procedures and/or follow-up).

Where it's running

• The First Affiliated Hospital of Guangxi Medical University
  Nanning, Guangxi, China Recruiting

Study contacts

• Principal investigator: Yuan Wu, MD, PhD — First Affiliated Hospital of Guangxi Medical University
• Study coordinator: Dong Pan, MD, PhD
• Email: dongpan012@hotmail.com
• Phone: 86-156 2648 3251

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Mobilisation After Endovascular Stroke Treatment

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.