Comparing endovascular therapy and best medical treatment for mild acute stroke with large vessel occlusion

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of endovascular therapy (EVT) compared to best medical management in patients experiencing mild acute ischemic stroke with a radiologically confirmed large vessel occlusion (LVO). It focuses on patients with a National Institutes of Health Stroke Scale (NIHSS) score of 2-5, who are at risk for poor outcomes despite mild symptoms. The trial aims to determine if EVT can improve functional outcomes and reduce the risk of early neurological deterioration in this specific patient population. Randomization will occur within 24 hours of stroke onset, ensuring timely intervention.

Why it matters

Who can join: the full rules

1. Aged 18 years or older;
2. The time from onset of acute ischemic stroke to randomization is within 24 hours. Onset time is defined as the patient's Last Known Well (LKW);
3. Low NIHSS score (2-5 points), with at least one of the following items:

   1. Altered mental status (lethargy or worse);
   2. Facial palsy (facial weakness score ≥ 1 point);
   3. Motor dysfunction (limb weakness score ≥ 1 point);
   4. Aphasia (language disturbance score ≥ 1 point);
   5. Hemispatial neglect (neglect score ≥ 1 point);
4. Intracranial internal carotid artery, proximal M1 or M2 segment of middle cerebral artery occlusion confirmed by cerebral CTA/MRA/DSA before randomization, which is identified as the culprit vessel for stroke;
5. All patients receive CTP/MR perfusion imaging, with a volume of perfusion delay (Tmax\>6 s) ≥ 50 mL;
6. Written informed consent is obtained from the patient or legal surrogate, with agreement for long-term follow-up.

Where it's running

• The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College
  Wuhu, Anhui, China Recruiting

Study contacts

• Study coordinator: Zhiming Zhou, PhD
• Email: neuro_depar@hotmail.com
• Phone: (++)86-(+)-553-5739543

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.