Dynamic brain blood vessel changes after a stroke and how they relate to recovery
Official title: Dynamic cerebrovascular morphology changes in acute ischemic stroke
Funded at University of California Riverside · NIH-11306002 · Data updated 2026-11-12
This project looks at how blood vessels in the brain change after an acute ischemic stroke and whether those changes can help predict a patient’s recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | April 19, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $599,940 |
| NIH project number | 5R01NS131554-03 |
| Project ID | NIH-11306002 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have experienced an acute ischemic stroke and are receiving reperfusion therapy or standard care.
✕Less likely to help
Patients without access to advanced imaging or those not undergoing reperfusion therapy may have limited direct benefits.
What this research studies
After an acute ischemic stroke, blood flow patterns in the brain can change as the vessels adapt and new pathways form. The study will analyze imaging data to map how cerebrovascular morphology evolves over time and how these changes relate to outcomes after reperfusion therapy. By turning detailed vessel features into prediction markers, clinicians may better tailor treatments and anticipate complications. The research is centered on people who have had a stroke and are undergoing standard care, using advanced imaging to derive meaningful insights.
Why it matters
Potential benefit: If successful, this work could improve predictions of stroke outcomes and help guide treatment decisions to optimize recovery.
How similar studies have gone: Prior research has linked vessel morphology with stroke outcomes, but this project aims to enhance predictive models with dynamic, time-sensitive vascular features.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Laksari, Kaveh — University of California Riverside
- Study coordinator: Laksari, Kaveh
Related research
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-
Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
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A Mayo Clinic team is testing a nanoparticle-delivered tPA approach to help dissolve clots more effectively in people with acute ischemic stroke due to large vessel blockage.
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A new off-the-shelf cell therapy using engineered regulatory T cells could help people who have an ischemic stroke recover by reducing inflammation and promoting tissue repair.
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Fast penumbral imaging to guide stroke treatment
Aims to develop quick MRI techniques to identify tissue at risk in acute ischemic stroke and help decide whether to use advanced clot-busting treatment.
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Circadian factors shaping reperfusion success in acute stroke
This grant looks at how the body’s internal clock might influence how well stroke patients respond to clot-busting or clot-removal treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.