Prognostic prediction model for patients with acute stroke undergoing endovascular therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop a prognostic prediction model for patients with acute ischemic stroke who are undergoing endovascular therapy. It will utilize machine learning techniques to analyze a large dataset, incorporating not only baseline patient variables but also intraoperative and postoperative factors that may influence neurological outcomes. The goal is to create a more comprehensive tool that can guide individualized treatment decisions and improve patient prognoses. The study will include patients with confirmed intracranial large artery occlusion and will focus on optimizing perioperative management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years;
* NIHSS score ≥4;
* Image-confirmed (CTA/MRA/DSA) intracranial large artery occlusion;
* ASPECT (anterior circulation) or PC-ASPECT (posterior circulation) score ≥3;
* Endovascular treatment including arterial thrombolysis, mechanical thrombolysis, and angioplasty (onset to puncture time is recommended to be less than 8 hours for anterior circulation and less than 12 hours for posterior circulation; those exceeding the time window will be determined by the neurointerventionalist through imaging assessment);
* Signed informed consent by the patient or legal representative

Exclusion Criteria:

* Pre-stroke mRS score \>2;
* Intracranial bleeding disorders: cerebral hemorrhage, subarachnoid hemorrhage, etc.;
* presence of coagulation disorders, history of systemic bleeding, history of thrombocytopenia or neutropenia;
* Renal insufficiency with elevated blood creatinine (greater than 2 times the upper limit of normal);
* Presence of severe cardiopulmonary disease that, in the opinion of the investigator, makes participation in this study unsuitable; patients with a life expectancy of less than 3 months or otherwise unable to complete this study;
* Contraindication to DSA examination, severe contrast allergy or absolute contraindication to iodine contrast; women of childbearing age who have a negative pregnancy test but refuse to use effective contraception, are pregnant or breast feeding;
* Those who are unable to complete the study due to psychiatric disorders, cognitive or mood disorders;
* Other patients who, in the opinion of the investigator, are not suitable for enrollment in the study (specify reason).

Where it's running

• Beijing Tiantan Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Ruquan Han
• Email: ruquan.han@gmail.com
• Phone: 8610-59976660

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.