New nanomedicine approach for treating acute ischemic stroke
Official title: Next-generation nanomedicine for acute ischemic stroke
Funded at Nanomuse, LLC · NIH-10603229 · Data updated 2026-11-12
This study is testing a new way to deliver brain-protecting medications directly to the brain for people who have had a stroke, hoping to help them recover better after treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nanomuse, LLC NIH-funded |
| Lab location | 1 site (Princeton Junction, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $300,454 |
| NIH project number | 1R41NS130812-01 |
| Project ID | NIH-10603229 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an acute ischemic stroke and are undergoing treatment.
✕Less likely to help
Patients who have not had a stroke or those with other unrelated medical conditions may not benefit from this research.
What this research studies
This research focuses on developing advanced nanocarriers to deliver neuroprotective drugs specifically to the brain during acute ischemic stroke. By utilizing a novel technology that binds to a specific brain marker, the researchers aim to significantly enhance drug delivery, improving outcomes for patients who have undergone mechanical thrombectomy. The study will explore the effectiveness of these nanocarriers loaded with corticosteroids in reducing brain damage and improving recovery after stroke. Patients may benefit from a more targeted treatment that addresses the secondary injuries caused by stroke.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced brain damage for stroke patients.
How similar studies have gone: Previous research has shown promise with similar nanocarrier approaches, indicating potential for success in this novel application.
Where this research is happening
-
Nanomuse, LLC
Princeton Junction, United States Active
Researchers
- Principal investigator: Brenner, Jacob — Nanomuse, LLC
- Study coordinator: Brenner, Jacob
Related research
Other NIH-funded projects on the same topics.
-
Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
A research project is creating better computer models and animal studies to help remove clots more safely and effectively in people who have an acute ischemic stroke.
-
Nanoparticle-delivered tPA to overcome clot resistance in acute ischemic stroke
A Mayo Clinic team is testing a nanoparticle-delivered tPA approach to help dissolve clots more effectively in people with acute ischemic stroke due to large vessel blockage.
-
Engineered tissue regulatory T cells as a treatment for stroke
A new off-the-shelf cell therapy using engineered regulatory T cells could help people who have an ischemic stroke recover by reducing inflammation and promoting tissue repair.
-
Fast penumbral imaging to guide stroke treatment
Aims to develop quick MRI techniques to identify tissue at risk in acute ischemic stroke and help decide whether to use advanced clot-busting treatment.
-
Circadian factors shaping reperfusion success in acute stroke
This grant looks at how the body’s internal clock might influence how well stroke patients respond to clot-busting or clot-removal treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.