Condition

Large Vessel Occlusion clinical trials and research

• 18Clinical trials
• 2NIH research projects
• 1New in 30 days
• 8Countries

Newest Large Vessel Occlusion clinical trials

All recruiting trials (18)

• Sevoflurane vs. Propofol for anesthesia in stroke patients undergoing clot-removal

  This study tests whether sevoflurane or propofol used for anesthesia during endovascular treatment of an acute ischemic stroke affects the final brain damage and recovery.

  Recruiting Phase 3 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona · NCT07902791

• Tenecteplase or Reteplase Bridging Before Thrombectomy in Acute Ischemic Stroke

  This trial tests whether giving tenecteplase or reteplase before mechanical thrombectomy helps people with acute ischemic stroke due to large vessel occlusion, compared with doing thrombectomy alone.

  Recruiting Phase 3 Beijing Tiantan Hospital · Beijing, Beijing Municipality and 4 other locations · NCT07748039

• Intra-arterial Alteplase after successful reperfusion following mechanical thrombectomy

  This trial tests whether giving a small amount of alteplase directly into the artery after a successful thrombectomy helps adults with acute ischemic stroke recover better.

  Recruiting at 9 sites Phase 3 115 People's Hospital · An Giang and 12 other locations · NCT07727395

• Sivelestat added to endovascular clot retrieval for acute anterior circulation stroke

  This study tests whether giving sivelestat sodium alongside mechanical thrombectomy helps improve outcomes for adults with acute ischemic stroke due to large vessel occlusion.

  Recruiting at 2 sites Xuanwu Hospital, Beijing · Weifang, Shandong and 1 other locations · NCT07552610

• Injecting methylprednisolone into the artery right after clot removal for large-vessel stroke

  This trial will test whether giving methylprednisolone into the artery immediately after successful clot removal, followed by three days of IV methylprednisolone, helps adults with anterior large-vessel occlusion strokes recover better.

  Recruiting Phase 2 Tang-Du Hospital · Xi'an, Shaanxi · NCT07516522

• Non-invasive vagus nerve stimulation to lower inflammation and brain injury markers after acute ischemic stroke

  This test tries whether adding non-invasive vagus nerve stimulation to usual care lowers inflammation and blood markers of brain injury in adults with acute ischemic stroke from a large vessel occlusion.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07404852

• Head-of-bed position after clot-removal stroke therapy

  This study tests whether keeping the head of the bed flat (0 degrees) after thrombectomy improves recovery compared with a raised position in adults who had an ischemic stroke due to large vessel blockage.

  Recruiting at 2 sites Population Health Research Institute · Greater Sudbury, Ontario and 1 other locations · NCT07367633

• Tenecteplase before transfer for anterior circulation large-vessel stroke (4.5–24 hours)

  This will test whether a single bolus of tenecteplase given at the first hospital before transfer helps people with anterior circulation large-vessel ischemic stroke who present 4.5–24 hours after they were last well.

  Recruiting at 2 sites Phase 3 Xuanwu Hospital, Beijing · Beijing, Beijing Municipality and 1 other locations · NCT07253181

• Cyclic vs Static Manual Aspiration for Acute Large Vessel Occlusion Stroke

  A randomized trial tests whether cyclic (plunger) suction or continuous suction works better to remove clots in adults with acute ischemic stroke from large vessel blockage.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07231380

• CONDA stent retriever for reopening large-vessel blockages in acute ischemic stroke.

  The CONDA stent retriever will be tried to reopen blocked large brain arteries in adults with acute ischemic stroke treated within 24 hours of symptom onset.

  Recruiting Anaconda Biomed S.L. · Budapest and 1 other locations · NCT07174505

• Imaging to detect impaired microcirculatory reperfusion after clot removal

  This project tests whether CT perfusion scans done after clot removal can spot poor tiny-vessel blood flow in adults with large-vessel ischemic stroke.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT07099599

• Biobank for patients with large vessel occlusion stroke

  This study is collecting blood and clot samples from patients with large vessel occlusion strokes to see if analyzing them can help improve diagnosis and treatment for these patients.

  Recruiting at 4 sites First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui and 4 other locations · NCT06963489

• Rescue stenting and thrombolysis for large vessel ischemic stroke

  This study tests if combining rescue stenting with a clot-busting treatment can help adults who have a severe stroke and didn't get better with standard procedures.

  Recruiting at 7 sites ASST Santi Paolo e Carlo · Bergamo, Italy and 6 other locations · NCT06727006

• Comparing thrombectomy and medical management for stroke patients treated after 24 hours

  This study is testing if a special procedure to remove blood clots can help stroke patients who arrive more than 24 hours after their symptoms start, compared to just using medication.

  Recruiting Tianjin Huanhu Hospital · Tianjin, Tianjin Municipality · NCT06654375

• Combining cooling and thrombectomy for acute stroke treatment

  This study tests if cooling the body after a stroke helps people recover better when combined with a procedure to open blocked blood vessels.

  Recruiting Phase 3 University of Freiburg · Freiburg im Breisgau · NCT06301412

• Evaluating treatment options for stroke patients presenting after 24 hours

  This study is trying to see if a special procedure or the best medical care can help stroke patients who arrive at the hospital more than 24 hours after their symptoms started.

  Recruiting Tianjin Huanhu Hospital · Tianjin, Tianjin Municipality · NCT06200753

• Registry for Endovascular Treatment of Acute Ischemic Stroke

  This study is trying to see how safe and effective a specific treatment for stroke is in helping patients recover after a blocked blood vessel.

  Recruiting Changhai Hospital · Shanghai · NCT05864638

• Registry for patients with acute ischemic stroke caused by large vessel occlusions

  This study is collecting information from patients with acute ischemic stroke caused by large vessel blockages to see if a special treatment works better than standard care.

  Recruiting at 4 sites Tianjin Huanhu Hospital · Tianjin, Tianjin Municipality and 3 other locations · NCT05659160

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Optical brain monitoring to detect large vessel blockage in stroke patients

  A lightweight, non-invasive optical test helps identify large vessel blockage in patients with suspected stroke so they can be routed quickly to the right hospital.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11385970

• Improving blood flow in stroke patients with large vessel occlusion

  This study is looking at a new way to help people who have had a serious type of stroke by using a special treatment called Lamiflo™ that improves blood flow, and it's for patients who might be eligible based on their imaging results.

  NIH research Shearit, LLC · Albuquerque, United States · NIH-10820012

Related topics

Quick answers

How many Large Vessel Occlusion clinical trials are recruiting right now?

18, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in China (9 trials), United States (3 trials), Spain (2 trials), Germany (1 trial), Hungary (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 5, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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