Improving treatment for acute ischemic stroke using advanced modeling techniques
Official title: Modeling of Acute Ischemic Stroke for Improving Mechanical Thrombectomy
Funded at Pennsylvania State University, the · NIH-10613506 · Data updated 2026-11-12
This study is looking at how blood clots form in the brain and why some can be removed easily while others can't, with the goal of helping doctors improve treatments for people who have had a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | May 4, 2020 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $605,773 |
| NIH project number | 5R01HL146921-04 |
| Project ID | NIH-10613506 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced an acute ischemic stroke and are undergoing or considering mechanical thrombectomy.
✕Less likely to help
Patients who have not experienced an acute ischemic stroke or those with other types of strokes may not benefit from this research.
What this research studies
This research focuses on understanding the complex processes that lead to acute ischemic strokes (AIS) by developing computational models that simulate thrombosis and embolization in the brain's blood vessels. By using patient-specific anatomy and blood chemistry, the study aims to identify why some blood clots can be removed effectively while others cannot. The researchers will validate their models through ex vivo experiments that mimic real-life blood flow conditions, providing insights that could enhance the effectiveness of mechanical thrombectomy procedures. Ultimately, this work seeks to improve patient outcomes following AIS.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for acute ischemic stroke, potentially reducing mortality and improving recovery rates.
How similar studies have gone: Previous research has shown promise in using computational models to understand thrombosis, indicating that this approach could yield valuable insights.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Manning, Keefe B — Pennsylvania State University, the
- Study coordinator: Manning, Keefe B
Related research
Other NIH-funded projects on the same topics.
-
Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
A research project is creating better computer models and animal studies to help remove clots more safely and effectively in people who have an acute ischemic stroke.
-
Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
Nanoparticle-delivered tPA to overcome clot resistance in acute ischemic stroke
A Mayo Clinic team is testing a nanoparticle-delivered tPA approach to help dissolve clots more effectively in people with acute ischemic stroke due to large vessel blockage.
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Engineered tissue regulatory T cells as a treatment for stroke
A new off-the-shelf cell therapy using engineered regulatory T cells could help people who have an ischemic stroke recover by reducing inflammation and promoting tissue repair.
-
Fast penumbral imaging to guide stroke treatment
Aims to develop quick MRI techniques to identify tissue at risk in acute ischemic stroke and help decide whether to use advanced clot-busting treatment.
-
Circadian factors shaping reperfusion success in acute stroke
This grant looks at how the body’s internal clock might influence how well stroke patients respond to clot-busting or clot-removal treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.