Improving treatment for acute ischemic stroke using advanced modeling techniques
Modeling of Acute Ischemic Stroke for Improving Mechanical Thrombectomy
['FUNDING_R01'] · PENNSYLVANIA STATE UNIVERSITY, THE · NIH-10613506
This study is looking at how blood clots form in the brain and why some can be removed easily while others can't, with the goal of helping doctors improve treatments for people who have had a stroke.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIVERSITY, THE (nih funded) |
| Locations | 1 site (UNIVERSITY PARK, UNITED STATES) |
| Trial ID | NIH-10613506 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the complex processes that lead to acute ischemic strokes (AIS) by developing computational models that simulate thrombosis and embolization in the brain's blood vessels. By using patient-specific anatomy and blood chemistry, the study aims to identify why some blood clots can be removed effectively while others cannot. The researchers will validate their models through ex vivo experiments that mimic real-life blood flow conditions, providing insights that could enhance the effectiveness of mechanical thrombectomy procedures. Ultimately, this work seeks to improve patient outcomes following AIS.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced an acute ischemic stroke and are undergoing or considering mechanical thrombectomy.
Not a fit: Patients who have not experienced an acute ischemic stroke or those with other types of strokes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for acute ischemic stroke, potentially reducing mortality and improving recovery rates.
How similar studies have performed: Previous research has shown promise in using computational models to understand thrombosis, indicating that this approach could yield valuable insights.
Where this research is happening
UNIVERSITY PARK, UNITED STATES
- PENNSYLVANIA STATE UNIVERSITY, THE — UNIVERSITY PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MANNING, KEEFE B — PENNSYLVANIA STATE UNIVERSITY, THE
- Study coordinator: MANNING, KEEFE B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.