Investigating vessel perforation during thrombectomy for stroke treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze complications arising from thrombectomy procedures for acute ischemic stroke, specifically focusing on vessel perforations. Researchers will identify factors that increase the likelihood of these perforations and examine imaging data to understand their causes. The study seeks to develop a classification system for these events to aid in immediate treatment decisions and improve overall safety during thrombectomy. By comparing outcomes between patients with and without perforations, the study hopes to enhance emergency responses and treatment protocols.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years at time of thrombectomy
* Acute ischemic stroke with occlusion of one or several intracranial arteries and subsequent thrombectomy.
* Target cohort: Occurrence of intracranial perforation during thrombectomy with evidence of contrast extravasation in at least one diagnostic angiography series.
* Comparison cohort: No perforation during thrombectomy. Every patient in the comparison group is matched to one patient in the target population. Matching will be carried out with respect to age, gender, participating center and location of the vascular occlusion.

Exclusion Criteria:

* Presence of a documented rejection
* Presence of both ischemic stroke and intracranial hemorrhage on pre-interventional imaging.
* Patients with intracranial dissection without active contrast extravasation.
* Patients with rupture of a pre-existing intracranial aneurysm during thrombectomy.
* Patients with contrast medium extravasation into a venous space instead of free contrast medium extravasation, e.g. the cavernous sinus with consecutive development of a carotid-cavernous fistula.

Where it's running

• University Hospital Basel
  Basel, Switzerland Recruiting

Study contacts

• Principal investigator: Victor Schulze-Zachau, MD — University Hospital, Basel, Switzerland
• Study coordinator: Victor Schulze-Zachau, MD
• Email: Victor.schulze-zachau@usb.ch
• Phone: +41 61 328 56 32

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.