Assessing treatment strategies for stroke patients with atrial fibrillation
Multimodal Prognostic Assessment of Acute Ischemic Stroke Patients With Atrial Fibrillation: a Prospective, Multicenter, Observational Study (IAT-CLOSURE)
Jinan Central Hospital · NCT06548269
This study is testing different treatment options for stroke patients with atrial fibrillation to see which one helps them recover better and prevents future strokes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Jinan Central Hospital (other) |
| Locations | 1 site (Jinan, Shandong) |
| Trial ID | NCT06548269 on ClinicalTrials.gov |
What this trial studies
This study investigates the safety and outcomes of various treatment strategies for patients with acute ischemic stroke and atrial fibrillation. It focuses on comparing best medical therapy, including oral anticoagulation and antiplatelet therapy, with left atrial appendage closure. The study employs a multimodal assessment approach, integrating brain and cardiologic evaluations to optimize secondary prevention of stroke. By utilizing prolonged cardiac monitoring, the study aims to improve detection rates of atrial fibrillation in stroke patients and assess the prognostic implications of AF burden.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old who have experienced an acute ischemic stroke within the last 14 days and have been diagnosed with non-valvular atrial fibrillation.
Not a fit: Patients with pacemakers, implantable cardioverter defibrillators, or those who have had their left atrial appendage removed will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies and better outcomes for patients with acute ischemic stroke and atrial fibrillation.
How similar studies have performed: Other studies have shown success in using prolonged cardiac monitoring to detect atrial fibrillation in stroke patients, indicating that this approach has been validated in similar contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age \> 18 years old； 2. Acute ischemic stroke with onset ≤ 14 days； 3. Previously or during this hospitalization diagnosed with non-valvular atrial fibrillation; 4. Informed consent obtained from the patient or his/her legal representative； Exclusion Criteria: 1. Pacemaker, implantable cardioverter defibrillator or implantable cardiac monitor; 2. Left atrial appendage has been removed or post occlusion device implantation; 3. Transient AF secondary to other reversible disorders； 4. Life expectancy less than 1 year; 5. Patients that cannot complete subsequent follow-up (e.g. no fixed residence, overseas patients, etc.); 6. Females who are pregnant or in lactation; 7. Participating in other clinical trials that could confound the evaluation of the study; 8. Other circumstances that the investigator considers inappropriate for participation or may pose a significant risk to patients.
Where this trial is running
Jinan, Shandong
- Jinan Central Hospital — Jinan, Shandong, China (RECRUITING)
Study contacts
- Study coordinator: Liqun Jiao
- Email: liqunjiao@sina.cn
- Phone: 13911224991
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Ischemic Stroke, Atrial Fibrillation, Atrial fibrillation, AF burden, Left atrial appendage closure