Assessing treatment strategies for stroke patients with atrial fibrillation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the safety and outcomes of various treatment strategies for patients with acute ischemic stroke and atrial fibrillation. It focuses on comparing best medical therapy, including oral anticoagulation and antiplatelet therapy, with left atrial appendage closure. The study employs a multimodal assessment approach, integrating brain and cardiologic evaluations to optimize secondary prevention of stroke. By utilizing prolonged cardiac monitoring, the study aims to improve detection rates of atrial fibrillation in stroke patients and assess the prognostic implications of AF burden.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \> 18 years old；
2. Acute ischemic stroke with onset ≤ 14 days；
3. Previously or during this hospitalization diagnosed with non-valvular atrial fibrillation;
4. Informed consent obtained from the patient or his/her legal representative；

Exclusion Criteria:

1. Pacemaker, implantable cardioverter defibrillator or implantable cardiac monitor;
2. Left atrial appendage has been removed or post occlusion device implantation;
3. Transient AF secondary to other reversible disorders；
4. Life expectancy less than 1 year;
5. Patients that cannot complete subsequent follow-up (e.g. no fixed residence, overseas patients, etc.);
6. Females who are pregnant or in lactation;
7. Participating in other clinical trials that could confound the evaluation of the study;
8. Other circumstances that the investigator considers inappropriate for participation or may pose a significant risk to patients.

Where it's running

• Jinan Central Hospital
  Jinan, Shandong, China Recruiting

Study contacts

• Study coordinator: Liqun Jiao
• Email: liqunjiao@sina.cn
• Phone: 13911224991

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.