Using remote ischemic conditioning to improve outcomes in acute ischemic stroke patients undergoing thrombectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of remote ischemic conditioning (RIC) in patients with acute ischemic stroke caused by large vessel occlusion who are undergoing endovascular thrombectomy. The study aims to determine if RIC can provide neuroprotection and improve functional outcomes by reducing reperfusion injury. Participants will receive either a 14-day or 30-day RIC regimen alongside standard medical management and thrombectomy. The trial will assess the impact of RIC on patient recovery and survival rates post-stroke.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age≥18 years；
2. Acute ischemic stroke due to large vessel occlusion in the anterior circulation that is not suitable for intravenous thrombolytic therapy, or has contraindications to intravenous thrombolytic therapy, or treated with intravenous thrombolytic therapy without recanalization;
3. Large vessel occlusion confirmed by computed tomography angiography (CTA) or magnetic resonance angiography (MRA), including the occlusion of the intracranial segment of the internal carotid artery (ICA) and M1 segment of the middle cerebral artery (MCA), is the cause of symptoms, and mechanical thrombectomy is planned within 24 hours from the time last known well;
4. Baseline score of the National Institutes of Health Stroke Scale (NIHSS) ≥ 6 points;
5. Patients or family members signed a written informed consent form.

Exclusion Criteria:

1. Imaging examination revealed the presence of multiple vascular supply areas of cerebral infarction (such as the simultaneous presence of infarction in both anterior and posterior circulation);
2. Absence of femoral artery pulsation, extremely difficult intravascular access, or extremely tortuous large vessels, which are expected to result in the inability to undergo timely endovascular treatment;
3. Difficult-to-control hypertension: continuous monitoring upon admission shows systolic blood pressure ≥180mmHg, or diastolic blood pressure ≥100mmHg;
4. Coma or lethargy patients (consciousness level score ≥2 in NIHSS);
5. Unable to obtain an accurate baseline NIHSS score;
6. Pre-stroke modified Rankin Scale (mRS) score \>1;
7. Baseline ASPECTS score ≤5;
8. Presence of bleeding tendency, deficiency of coagulation factors, or oral anticoagulant therapy with INR \> 3.0;
9. Baseline blood glucose \<2.7mmol/L or \>22.2mmol/L;
10. Baseline platelet count \< 30\*10\^9/L;
11. Severe known renal impairment defined as requiring dialysis (hemodialysis or peritoneal dialysis), or if known creatinine clearance rate \<30mL/min;
12. Cranial CT or MRI shows intracranial hemorrhage;
13. Cranial CT or MRI shows midline deviation and significant occupying effect;
14. Clinical history, previous imaging examinations, or clinical judgment suggesting intracranial tumors, arteriovenous malformations, or intracranial arterial dissection;
15. History of head injury in the past 3 months;
16. History of life-threatening allergy to contrast agents, nickel, titanium metal, or their alloys;
17. Pregnancy, if women of childbearing age have a positive urinary or serum β-human chorionic gonadotropin (β-hCG) test or are breastfeeding；
18. The life expectancy of patients is less than 6 months, and they cannot be evaluated within 3 months;
19. Limb deformity, soft tissue injury, or other conditions that affect the implementation of distant ischemia adaptation therapy;
20. Participating in other ongoing clinical trials;
21. Other conditions that the investigators believe are not suitable for participation in this study.

Where it's running

• Suzhou Municipal Hospital of Anhui Province
  Suzhou, Anhui, China Recruiting
• Taihe County People's Hospital
  Taihe Chengguanzhen, Anhui, China Recruiting
• Tongling People's Hospital
  Tongling, Anhui, China Recruiting
• Beijing Luhe Hospital affiliated to Capital Medical University
  Beijing, Beijing Municipality, China Recruiting
• Beijing Fangshan District First Hospital
  Beijing, Beijing Municipality, China Recruiting
• Zhangzhou Municipal Hospital of Fujian Province
  Zhangzhou, Fujian, China Recruiting

+20 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Xunming Ji, MD, PhD
• Email: jixm@ccmu.edu.cn
• Phone: 010-8319-9439

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Minocycline after successful recanalization in acute anterior circulation stroke

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• Intracranial Recanalization with LT3001 in Acute Ischemic Stroke

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  Recruiting Phase 2 Lumosa Therapeutics Co., Ltd. · Taichung · NCT07890298

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.